Reactome | p-Y-IRS1,p-Y-IRS2 [cytosol]

Schema > DefinedSet > Entries

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-MMU-5686316] GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] - Mus musculus [Complex:R-MMU-74694] p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] - Mus musculus [Complex:R-MMU-198299] Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] - Mus musculus
consumedByEvent	[Reaction:R-MMU-74737] p-Y-IRS1,p-Y-IRS2 bind PI3K - Mus musculus [Reaction:R-MMU-74736] GRB2-1:SOS1 binds p-IRS1,p-IRS2 - Mus musculus
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	9989004
displayName	p-Y-IRS1,p-Y-IRS2 [cytosol]
hasMember	[EntityWithAccessionedSequence:R-MMU-74772] phospho-Irs1 [cytosol] - Mus musculus [EntityWithAccessionedSequence:R-MMU-74774] phospho-Irs2 [cytosol] - Mus musculus
inDisease	false
inferredFrom	[DefinedSet:R-HSA-112322] p-Y-IRS1,p-Y-IRS2 [cytosol] - Homo sapiens
maxDepth	2
name	p-Y-IRS1,p-Y-IRS2
producedByEvent	[Reaction:R-MMU-5686315] GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates - Mus musculus [Reaction:R-MMU-74712] Dissociation of IRS-P from insulin receptor - Mus musculus
schemaClass	DefinedSet
species	[Species:48892] Mus musculus
stId	R-MMU-112322

(input)	[Reaction:R-MMU-74737] p-Y-IRS1,p-Y-IRS2 bind PI3K [Reaction:R-MMU-74736] GRB2-1:SOS1 binds p-IRS1,p-IRS2
(hasComponent)	[Complex:R-MMU-74694] p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] [Complex:R-MMU-5686316] GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] [Complex:R-MMU-74695] p-Y-IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] [Complex:R-MMU-109800] GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] [Complex:R-MMU-198299] Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane]
(output)	[Reaction:R-MMU-5686315] GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates [Reaction:R-MMU-74712] Dissociation of IRS-P from insulin receptor
(inferredTo)	[DefinedSet:R-HSA-112322] p-Y-IRS1,p-Y-IRS2 [cytosol]