Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
p-Y-IRS1,p-Y-IRS2 [cytosol]
Stable Identifier
R-MMU-112322
Type
Set [DefinedSet]
Species
Mus musculus
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Signal Transduction (Mus musculus)
MAPK family signaling cascades (Mus musculus)
MAPK1/MAPK3 signaling (Mus musculus)
RAF/MAP kinase cascade (Mus musculus)
RAS GEFs promote RAS nucleotide exchange (Mus musculus)
RAS GEFs [plasma membrane] (Mus musculus)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by Insulin receptor (Mus musculus)
Insulin receptor signalling cascade (Mus musculus)
IRS activation (Mus musculus)
Dissociation of IRS-P from insulin receptor (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
p-Y-IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
Phosphorylation of IRS (Mus musculus)
p-Y-IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
IRS-mediated signalling (Mus musculus)
PI3K Cascade (Mus musculus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Mus musculus)
PI3K-containing complexes [cytosol] (Mus musculus)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
SOS-mediated signalling (Mus musculus)
GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Mus musculus)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
p-Y-IRS1,p-Y-IRS2 bind PI3K (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
Signal attenuation (Mus musculus)
GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Mus musculus)
GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 (Mus musculus)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
Signaling by NTRKs (Mus musculus)
Signaling by NTRK1 (TRKA) (Mus musculus)
PI3K/AKT activation (Mus musculus)
Active IRS recruits PI3K to the plasma membrane and activates it (Mus musculus)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Mus musculus)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
PI3K produces PIP3 and other phosphatidyl inositides (Mus musculus)
Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Mus musculus)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Mus musculus)
IGF1R signaling cascade (Mus musculus)
IRS-related events triggered by IGF1R (Mus musculus)
IRS-mediated signalling (Mus musculus)
PI3K Cascade (Mus musculus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Mus musculus)
PI3K-containing complexes [cytosol] (Mus musculus)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
SOS-mediated signalling (Mus musculus)
GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Mus musculus)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
p-Y-IRS1,p-Y-IRS2 bind PI3K (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
Participants
members
phospho-Irs1 [cytosol]
(Mus musculus)
phospho-Irs2 [cytosol]
(Mus musculus)
Participates
as an input of
p-Y-IRS1,p-Y-IRS2 bind PI3K (Mus musculus)
GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Mus musculus)
as a component of
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Mus musculus)
GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
p-Y-IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Mus musculus)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Mus musculus)
as an output of
GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Mus musculus)
Dissociation of IRS-P from insulin receptor (Mus musculus)
Inferred From
p-Y-IRS1,p-Y-IRS2 [cytosol]
(Homo sapiens)
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text