Reactome | Binding of Gbeta/gamma to GIRK/Kir3 channels

Schema > Reaction > Entries

Binding of Gbeta/gamma to GIRK/Kir3 channels Show undefined attributes

authored	[InstanceEdit:1063707] Mahajan, SS, 2010-11-25
catalystActivity	[CatalystActivity:1013016] G protein-coupled GABA receptor activity of GABBR1:GABBR2:GABA [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:1013009] Mahajan, SS, 2010-11-11
dbId	1013012
displayName	Binding of Gbeta/gamma to GIRK/Kir3 channels
edited	[InstanceEdit:1056680] D'Eustachio, P, 2010-11-24
eventOf	[Pathway:R-HSA-1296041] Activation of G protein gated Potassium channels - Homo sapiens
followingEvent	[Reaction:R-HSA-1013020] Activation of GIRK/Kir3 Channels - Homo sapiens
input	[Complex:R-HSA-1013017] GABA B receptor G-protein beta-gamma complex [plasma membrane] [DefinedSet:R-HSA-975294] Kir heterotetramers [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1013773] GABAB-GIRK2-mediated signaling in Down syndrome
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Binding of Gbeta/gamma to GIRK/Kir3 channels
orthologousEvent	[Reaction:R-CEL-1013012] Binding of Gbeta/gamma to GIRK/Kir3 channels - Caenorhabditis elegans [Reaction:R-DME-1013012] Binding of Gbeta/gamma to GIRK/Kir3 channels - Drosophila melanogaster [Reaction:R-XTR-1013012] Binding of Gbeta/gamma to GIRK/Kir3 channels - Xenopus tropicalis [Reaction:R-SSC-1013012] Binding of Gbeta/gamma to GIRK/Kir3 channels - Sus scrofa [Reaction:R-BTA-1013012] Binding of Gbeta/gamma to GIRK/Kir3 channels - Bos taurus [Reaction:R-CFA-1013012] Binding of Gbeta/gamma to GIRK/Kir3 channels - Canis familiaris [Reaction:R-RNO-1013012] Binding of Gbeta/gamma to GIRK/Kir3 channels - Rattus norvegicus [Reaction:R-MMU-1013012] Binding of Gbeta/gamma to GIRK/Kir3 channels - Mus musculus
output	[Complex:R-HSA-1013011] GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane]
precedingEvent	[Reaction:R-HSA-1013013] Association of GABA B receptor with G protein beta-gamma subunits - Homo sapiens [Reaction:R-HSA-420688] GABAB heterodimeric receptor binds GABA - Homo sapiens
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:386898] Restituito, S, 2008-11-27 12:38:49
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1013012
summation	[Summation:1013756] The release of G beta gamma from Gi/o enables binding of G b...

Referrals

(hasEvent)	[Pathway:R-HSA-1296041] Activation of G protein gated Potassium channels [Pathway:R-HSA-997272] Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
(precedingEvent)	[Reaction:R-HSA-1013020] Activation of GIRK/Kir3 Channels