Reactome | Tyrosine phosphorylated IL6ST binds STAT3

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Tyrosine phosphorylated IL6ST binds STAT3 Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10328275
displayName	Tyrosine phosphorylated IL6ST binds STAT3
eventOf	[Pathway:R-CFA-9958825] Activation of STAT3 by cadherin engagement - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-9958871] Tyrosine phosphorylation of STAT3 by IL6 receptor - Canis familiaris
inferredFrom	[Reaction:R-HSA-9958878] Tyrosine phosphorylated IL6ST binds STAT3 - Homo sapiens
input	[EntityWithAccessionedSequence:R-CFA-539044] STAT3 [cytosol] [Complex:R-CFA-1112594] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Tyrosine phosphorylated IL6ST binds STAT3
output	[Complex:R-CFA-9958926] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:STAT3 [plasma membrane]
precedingEvent	[BlackBoxEvent:R-CFA-1112510] IL6ST is tyrosine phosphorylated - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-9958878
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-9958825] Activation of STAT3 by cadherin engagement
(precedingEvent)	[Reaction:R-CFA-9958871] Tyrosine phosphorylation of STAT3 by IL6 receptor
(inferredTo)	[Reaction:R-HSA-9958878] Tyrosine phosphorylated IL6ST binds STAT3

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