Reactome | ZNF598 and Ub:UBE2D1,2,3 bind stalled 80S ribosome

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ZNF598 and Ub:UBE2D1,2,3 bind stalled 80S ribosome Show undefined attributes

authored	[InstanceEdit:9948322] May, Bruce, 2025-05-19
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9948292] May, Bruce, 2025-05-19
dbId	9948317
displayName	ZNF598 and Ub:UBE2D1,2,3 bind stalled 80S ribosome
edited	[InstanceEdit:9948322] May, Bruce, 2025-05-19
eventOf	[Pathway:R-HSA-9954716] ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA - Homo sapiens
followingEvent	[Reaction:R-HSA-9948301] ZNF598 K63 polyubiquitinates RPS10 (eS10) and RPS20 (uS10) of the 40S ribosomal subunit - Homo sapiens
input	[Complex:R-HSA-9954725] 80S Ribosome:no-go mRNA:peptidyl-tRNA with elongating peptide [cytosol] [Complex:R-HSA-8953915] Ub:UBE2D1,2,3 [cytosol] [EntityWithAccessionedSequence:R-HSA-9948290] ZNF598 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9948316] Initiation of Quality Control during Poly(A) Translation Requires Site-Specific Ribosome Ubiquitination [LiteratureReference:9948288] ZNF598 and RACK1 Regulate Mammalian Ribosome-Associated Quality Control Function by Mediating Regulatory 40S Ribosomal Ubiquitylation [LiteratureReference:9949685] The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs [LiteratureReference:9949683] ZNF598 Is a Quality Control Sensor of Collided Ribosomes
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	ZNF598 and Ub:UBE2D1,2,3 bind stalled 80S ribosome
orthologousEvent	[Reaction:R-PFA-9948317] ZNF598 and Ub:UBE2D1,2,3 bind stalled 80S ribosome - Plasmodium falciparum [Reaction:R-DDI-9948317] ZNF598 and Ub:UBE2D1,2,3 bind stalled 80S ribosome - Dictyostelium discoideum [Reaction:R-CEL-9948317] ZNF598 and Ub:UBE2D1,2,3 bind stalled 80S ribosome - Caenorhabditis elegans [Reaction:R-DME-9948317] ZNF598 and Ub:UBE2D1,2,3 bind stalled 80S ribosome - Drosophila melanogaster [Reaction:R-GGA-9948317] ZNF598 and Ub:UBE2D1,2,3 bind stalled 80S ribosome - Gallus gallus [Reaction:R-XTR-9948317] ZNF598 and Ub:UBE2D1,2,3 bind stalled 80S ribosome - Xenopus tropicalis [Reaction:R-DRE-9948317] ZNF598 and Ub:UBE2D1,2,3 bind stalled 80S ribosome - Danio rerio [Reaction:R-SSC-9948317] ZNF598 and Ub:UBE2D1,2,3 bind stalled 80S ribosome - Sus scrofa [Reaction:R-BTA-9948317] ZNF598 and Ub:UBE2D1,2,3 bind stalled 80S ribosome - Bos taurus [Reaction:R-CFA-9948317] ZNF598 and Ub:UBE2D1,2,3 bind stalled 80S ribosome - Canis familiaris [Reaction:R-RNO-9948317] ZNF598 and Ub:UBE2D1,2,3 bind stalled 80S ribosome - Rattus norvegicus [Reaction:R-MMU-9948317] ZNF598 and Ub:UBE2D1,2,3 bind stalled 80S ribosome - Mus musculus
output	[Complex:R-HSA-9948313] ZNF598:Ub:UBE2D1,2,3:80S Ribosome:mRNA:peptidyl-tRNA with nascent peptide [cytosol]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9962796] Bennett, Eric J, 2025-08-09 [InstanceEdit:9962794] Ford, Pierce W, 2025-08-09 [InstanceEdit:9971505] Jafarnejad, Seyed Mehdi, 2025-11-07 [InstanceEdit:9971510] McGirr, Tom, 2025-11-07
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9948317
summation	[Summation:9949692] Due to features such as damaged nucleotides, strong secondar...
updateTrackers	[UpdateTracker:9971811] Update Tracker - [Reaction:9948317] ZNF598 and Ub:UBE2D1,2,3 bind stalled 80S ribosome - v95:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9971811] Update Tracker - [Reaction:9948317] ZNF598 and Ub:UBE2D1,2,3 bind stalled 80S ribosome - v95:[modifyText]
(hasEvent)	[Pathway:R-HSA-9954716] ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
(precedingEvent)	[Reaction:R-HSA-9948301] ZNF598 K63 polyubiquitinates RPS10 (eS10) and RPS20 (uS10) of the 40S ribosomal subunit

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