Reactome | ZNF598 and Ub:UBE2D1,2,3 bind stalled 80S ribosome

Schema > Reaction > Entries

ZNF598 and Ub:UBE2D1,2,3 bind stalled 80S ribosome Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10442298
displayName	ZNF598 and Ub:UBE2D1,2,3 bind stalled 80S ribosome
eventOf	[Pathway:R-BTA-9954716] ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-9948301] ZNF598 K63 polyubiquitinates RPS10 (eS10) and RPS20 (uS10) of the 40S ribosomal subunit - Bos taurus
inferredFrom	[Reaction:R-HSA-9948317] ZNF598 and Ub:UBE2D1,2,3 bind stalled 80S ribosome - Homo sapiens
input	[Complex:R-BTA-9954725] 80S Ribosome:no-go mRNA:peptidyl-tRNA with elongating peptide [cytosol] [Complex:R-BTA-8953915] Ub:UBE2D1,2,3 [cytosol] [EntityWithAccessionedSequence:R-BTA-9948290] ZNF598 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	ZNF598 and Ub:UBE2D1,2,3 bind stalled 80S ribosome
output	[Complex:R-BTA-9948313] ZNF598:Ub:UBE2D1,2,3:80S Ribosome:mRNA:peptidyl-tRNA with nascent peptide [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-9948317
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-9954716] ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
(precedingEvent)	[Reaction:R-BTA-9948301] ZNF598 K63 polyubiquitinates RPS10 (eS10) and RPS20 (uS10) of the 40S ribosomal subunit
(inferredTo)	[Reaction:R-HSA-9948317] ZNF598 and Ub:UBE2D1,2,3 bind stalled 80S ribosome