Reactome | CHD2-dependent H3.3 deposition at MYOG gene

Schema > Reaction > Entries

CHD2-dependent H3.3 deposition at MYOG gene Show undefined attributes

authored	[InstanceEdit:9937860] Rothfels, Karen, 2025-02-07
catalystActivity	[CatalystActivity:9943609] ATP hydrolysis activity of CHD2:MYOD heterodimer:MYOG gene with H3 nucleosome [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9943611] ATP hydrolysis activity of CHD2:MYOD heterodimer:MYOG gene with H3 nucleosome [nucleoplasm] Chd2 interacts with H3.3 to determine myogenic cell fate
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9943613] Rothfels, Karen, 2025-03-30
dbId	9943614
displayName	CHD2-dependent H3.3 deposition at MYOG gene
edited	[InstanceEdit:9937860] Rothfels, Karen, 2025-02-07
eventOf	[Pathway:R-HSA-9943411] CHD1 and CHD2 subfamily - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9943620] CHD2:MYOD heterodimer dependent MYOG gene expression - Homo sapiens
inferredFrom	[Reaction:R-MMU-9943615] Chd2 deposits H3.3 at Myog gene - Mus musculus
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-HSA-9943573] CHD2:MYOD heterodimer:MYOG gene with H3 nucleosome [nucleoplasm] [SimpleEntity:R-ALL-113518] H2O [nucleoplasm] 2 × [EntityWithAccessionedSequence:R-HSA-212295] H3F3A [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:9943396] Chd2 interacts with H3.3 to determine myogenic cell fate [LiteratureReference:9677086] Pask integrates hormonal signaling with histone modification via Wdr5 phosphorylation to drive myogenesis [LiteratureReference:9943545] Epigenetic Regulation of Myogenesis: Focus on the Histone Variants [LiteratureReference:9943533] Variant histone H3.3 is deposited at sites of nucleosomal displacement throughout transcribed genes while active histone modifications show a promoter-proximal bias [LiteratureReference:9943541] Epigenetic inheritance of cell differentiation status [LiteratureReference:9670117] Distinct factors control histone variant H3.3 localization at specific genomic regions [LiteratureReference:9943521] Transcription-coupled recruitment of human CHD1 and CHD2 influences chromatin accessibility and histone H3 and H3.3 occupancy at active chromatin regions [LiteratureReference:9943481] CHD1 motor protein is required for deposition of histone variant H3.3 into chromatin in vivo [LiteratureReference:9943382] Human CHD2 is a chromatin assembly ATPase regulated by its chromo- and DNA-binding domains
maxDepth	1
modified	[InstanceEdit:9974210] Rothfels, Karen, 2025-11-20
name	CHD2-dependent H3.3 deposition at MYOG gene
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-HSA-9943599] CHD2:MYOD heterodimer: MYOG gene with H3.3 nucleosome [nucleoplasm] [SimpleEntity:R-ALL-9668967] H+ [nucleoplasm] [SimpleEntity:R-ALL-113550] Pi [nucleoplasm] 2 × [DefinedSet:R-HSA-417237] Replicative histone H3 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9943571] CHD2 and MYOD heterodimer bind the MYOG gene - Homo sapiens
releaseDate	2026-03-25
releaseStatus	NEW
reviewStatus	[ReviewStatus:9821383] three stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9943614
summation	[Summation:9943570] CHD2 and MYOD are required for the expression of MYOG and ot...

Referrals

(hasEvent)	[Pathway:R-HSA-9943411] CHD1 and CHD2 subfamily
(precedingEvent)	[BlackBoxEvent:R-HSA-9943620] CHD2:MYOD heterodimer dependent MYOG gene expression
(inferredTo)	[Reaction:R-MMU-9943615] Chd2 deposits H3.3 at Myog gene