Reactome | TBX21 binds the IL12RB2 gene

Schema > Reaction > Entries

TBX21 binds the IL12RB2 gene Show undefined attributes

authored	[InstanceEdit:9942520] May, Bruce, 2025-03-17
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9942682] May, Bruce, 2025-03-19
dbId	9942698
displayName	TBX21 binds the IL12RB2 gene
edited	[InstanceEdit:9942520] May, Bruce, 2025-03-17
eventOf	[Pathway:R-HSA-9942503] Differentiation of naive CD4+ T cells to T helper 1 cells (Th1 cells) - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9942734] TBX21 positively regulates expression of IL12RB2 - Homo sapiens
inferredFrom	[Reaction:R-MMU-9943435] Tbx21 binds the Il12rb2 gene - Mus musculus
input	[EntityWithAccessionedSequence:R-HSA-8958138] IL12RB2 gene [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9942502] TBX21 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:9945893] T-bet and GATA3 orchestrate Th1 and Th2 differentiation through lineage-specific targeting of distal regulatory elements [LiteratureReference:9945883] The Th1 cell regulatory circuitry is largely conserved between human and mouse
maxDepth	1
modified	[InstanceEdit:9962434] May, Bruce, 2025-08-05
name	TBX21 binds the IL12RB2 gene
output	[Complex:R-HSA-9942755] TBX21:IL12RB2 gene [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-9942499] STAT proteins and NFATC1 positively regulate expression of TBX21 during differentiation of T helper 1 cells (Th1 cells) - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9962418] Barbutti, Isabella, 2025-08-04 [InstanceEdit:9962433] Lord, Graham M, 2025-08-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9942698
summation	[Summation:9942765] TBX21 (T-bet) binds the promoter and an intron of the IL12RB...

Referrals

(hasEvent)	[Pathway:R-HSA-9942503] Differentiation of naive CD4+ T cells to T helper 1 cells (Th1 cells)
(precedingEvent)	[BlackBoxEvent:R-HSA-9942734] TBX21 positively regulates expression of IL12RB2
(inferredTo)	[Reaction:R-MMU-9943435] Tbx21 binds the Il12rb2 gene

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