Reactome | TBX21 positively regulates expression of IL12RB2

Schema > BlackBoxEvent > Entries

TBX21 positively regulates expression of IL12RB2 Show undefined attributes

authored	[InstanceEdit:9942520] May, Bruce, 2025-03-17
category	omitted
compartment	[Compartment:7660] nucleoplasm [Compartment:876] plasma membrane
created	[InstanceEdit:9942682] May, Bruce, 2025-03-19
dbId	9942734
displayName	TBX21 positively regulates expression of IL12RB2
edited	[InstanceEdit:9942520] May, Bruce, 2025-03-17
eventOf	[Pathway:R-HSA-9942503] Differentiation of naive CD4+ T cells to T helper 1 cells (Th1 cells) - Homo sapiens
followingEvent	[Reaction:R-HSA-8950063] IL12RB2 binds JAK2 - Homo sapiens
inferredFrom	[BlackBoxEvent:R-MMU-9943450] Tbx21 (T-bet) positively regulates expression of Il12rb2 - Mus musculus
input	[EntityWithAccessionedSequence:R-HSA-8958138] IL12RB2 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:9945893] T-bet and GATA3 orchestrate Th1 and Th2 differentiation through lineage-specific targeting of distal regulatory elements
maxDepth	1
modified	[InstanceEdit:9962434] May, Bruce, 2025-08-05
name	TBX21 positively regulates expression of IL12RB2
output	[EntityWithAccessionedSequence:R-HSA-447249] IL12RB2 [plasma membrane]
precedingEvent	[Reaction:R-HSA-9942698] TBX21 binds the IL12RB2 gene - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
regulatedBy	[PositiveGeneExpressionRegulation:9942750] Positive gene expression regulation by 'TBX21:IL12RB2 gene [nucleoplasm]' [NegativeGeneExpressionRegulation:9942968] Negative gene expression regulation by 'p-S257-NFATC1 [nucleoplasm]'
releaseDate	2025-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9962418] Barbutti, Isabella, 2025-08-04 [InstanceEdit:9962433] Lord, Graham M, 2025-08-05
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9942734
summation	[Summation:9942739] TBX21 binds the IL12RB2 gene, which encodes a subunit of the...

Referrals

(precedingEvent)	[Reaction:R-HSA-8950063] IL12RB2 binds JAK2
(hasEvent)	[Pathway:R-HSA-9942503] Differentiation of naive CD4+ T cells to T helper 1 cells (Th1 cells)
(inferredTo)	[BlackBoxEvent:R-MMU-9943450] Tbx21 (T-bet) positively regulates expression of Il12rb2

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