Reactome | TRMT61B methylates adenosine-616 and adenosine-617 of MT-CYB mRNA

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TRMT61B methylates adenosine-616 and adenosine-617 of MT-CYB mRNA Show undefined attributes

authored	[InstanceEdit:9937506] May, Bruce, 2025-01-31
catalystActivity	[CatalystActivity:9937525] mRNA (adenine-N1-)-methyltransferase activity of TRMT61B tetramer [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:9937526] May, Bruce, 2025-02-01
dbId	9937529
displayName	TRMT61B methylates adenosine-616 and adenosine-617 of MT-CYB mRNA
edited	[InstanceEdit:9937506] May, Bruce, 2025-01-31
eventOf	[Pathway:R-HSA-9937008] Mitochondrial mRNA modification - Homo sapiens
input	2 × [SimpleEntity:R-ALL-2162265] AdoMet [mitochondrial matrix] [EntityWithAccessionedSequence:R-HSA-6792969] MT-CYB mRNA [mitochondrial matrix]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9937527] Base-Resolution Mapping Reveals Distinct m¹A Methylome in Nuclear- and Mitochondrial-Encoded Transcripts
maxDepth	1
modified	[InstanceEdit:9949648] May, Bruce, 2025-05-23
name	TRMT61B methylates adenosine-616 and adenosine-617 of MT-CYB mRNA
output	2 × [SimpleEntity:R-ALL-2162252] AdoHcy [mitochondrial matrix] [EntityWithAccessionedSequence:R-HSA-9937510] m1A616,617-MT-CYB mRNA [mitochondrial matrix]
precedingEvent	[BlackBoxEvent:R-HSA-6785722] Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the H strand transcript - Homo sapiens
releaseDate	2025-06-18
reviewStatus	[ReviewStatus:9821383] three stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9937529
summation	[Summation:9937588] TRMT61B methylates the N1 position in adenosine residues of ...

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[Pathway:R-HSA-9937008] Mitochondrial mRNA modification

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