TRMT61B methylates the N1 position in adenosine residues of ...

created [InstanceEdit:9937587] May, Bruce, 2025-02-03
dbId 9937588
displayName TRMT61B methylates the N1 position in adenosine residues of ...
literatureReference
modified [InstanceEdit:9938111] May, Bruce, 2025-02-10
schemaClass Summation
text TRMT61B methylates the N1 position in adenosine residues of tRNA (Chujo and Suzuki 2012) and mRNA (Li et al. 2017). TRMT61B methylates adenosine-616 and adenosine-617 residues of the MT-CYB mRNA. N1-methyladenosine in mitochondrial mRNA appears to cause ribosome stalling that results in reduced translation (Li et al. 2017). TRMT61B forms large homooligomeric complexes that are presumed to contain homotetramers (Chujo and Suzuki 2012, also PDB 2B25).
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