TRMT61B methylates adenosine-616 and adenosine-617 of MT-CYB mRNA

Stable Identifier
R-HSA-9937529
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
ReviewStatus
3/5
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TRMT61B methylates adenosine-616 and adenosine-617 of MT-CYB mRNA
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TRMT61B methylates the N1 position in adenosine residues of tRNA (Chujo and Suzuki 2012) and mRNA (Li et al. 2017). TRMT61B methylates adenosine-616 and adenosine-617 residues of the MT-CYB mRNA. N1-methyladenosine in mitochondrial mRNA appears to cause ribosome stalling that results in reduced translation (Li et al. 2017). TRMT61B forms large homooligomeric complexes that are presumed to contain homotetramers (Chujo and Suzuki 2012, also PDB 2B25).
Literature References
PubMed ID Title Journal Year
29107537 Base-Resolution Mapping Reveals Distinct m1A Methylome in Nuclear- and Mitochondrial-Encoded Transcripts

Li, X, Xiong, X, Zhang, M, Wang, K, Chen, Y, Zhou, J, Mao, Y, Lv, J, Yi, D, Chen, XW, Wang, C, Qian, SB, Yi, C

Mol Cell 2017
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Catalyst Activity

mRNA (adenine-N1-)-methyltransferase activity of TRMT61B tetramer [mitochondrial matrix]

Physical Entity
TRMT61B tetramer [mitochondrial matrix] (Homo sapiens)
Activity
mRNA (adenine-N1-)-methyltransferase activity (GO:0061953)
Authored
May, B  (2025-01-31)
Created
May, B  (2025-02-01)
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