Reactome | The RNA exosome in RNA exosome:NEXT:ZC3H18:CBCA:m7GpppN-RNA hydrolyzes RNA

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The RNA exosome in RNA exosome:NEXT:ZC3H18:CBCA:m7GpppN-RNA hydrolyzes RNA Show undefined attributes

authored	[InstanceEdit:9934545] May, Bruce, 2025-01-08
catalystActivity	[CatalystActivity:9934761] 3'-5'-RNA exonuclease activity of RNA exosome:NEXT:ZC3H18:CBCA:m7GpppN-RNA [nucleoplasm]
category	uncertain
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9934762] May, Bruce, 2025-01-10
dbId	9934763
displayName	The RNA exosome in RNA exosome:NEXT:ZC3H18:CBCA:m7GpppN-RNA hydrolyzes RNA
edited	[InstanceEdit:9934545] May, Bruce, 2025-01-08
eventOf	[Pathway:R-HSA-9930044] Nuclear RNA decay - Homo sapiens
input	[Complex:R-HSA-9934534] RNA exosome:NEXT:ZC3H18:CBCA:m7GpppN-RNA [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9935623] Intergenic RNA mainly derives from nascent transcripts of known genes [LiteratureReference:9934516] The human cap-binding complex is functionally connected to the nuclear RNA exosome [LiteratureReference:8985575] Interaction profiling identifies the human nuclear exosome targeting complex [LiteratureReference:9935627] Helicase-Dependent RNA Decay Illuminated by a Cryo-EM Structure of a Human Nuclear RNA Exosome-MTR4 Complex [LiteratureReference:9935634] Activities of human RRP6 and structure of the human RRP6 catalytic domain [LiteratureReference:433047] Reconstitution, activities, and structure of the eukaryotic RNA exosome
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	The RNA exosome in RNA exosome:NEXT:ZC3H18:CBCA:m7GpppN-RNA hydrolyzes RNA
orthologousEvent	[BlackBoxEvent:R-DME-9934763] The RNA exosome in RNA exosome:NEXT:ZC3H18:CBCA:m7GpppN-RNA hydrolyzes RNA - Drosophila melanogaster [BlackBoxEvent:R-SSC-9934763] The RNA exosome in RNA exosome:NEXT:ZC3H18:CBCA:m7GpppN-RNA hydrolyzes RNA - Sus scrofa [BlackBoxEvent:R-BTA-9934763] The RNA exosome in RNA exosome:NEXT:ZC3H18:CBCA:m7GpppN-RNA hydrolyzes RNA - Bos taurus [BlackBoxEvent:R-CFA-9934763] The RNA exosome in RNA exosome:NEXT:ZC3H18:CBCA:m7GpppN-RNA hydrolyzes RNA - Canis familiaris [BlackBoxEvent:R-RNO-9934763] The RNA exosome in RNA exosome:NEXT:ZC3H18:CBCA:m7GpppN-RNA hydrolyzes RNA - Rattus norvegicus [BlackBoxEvent:R-MMU-9934763] The RNA exosome in RNA exosome:NEXT:ZC3H18:CBCA:m7GpppN-RNA hydrolyzes RNA - Mus musculus
output	[Complex:R-HSA-9930043] CBCA complex [nucleoplasm] [Complex:R-HSA-9935998] NEXT homodimer [nucleoplasm] [Complex:R-HSA-9933578] RNA exosome [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9930040] ZC3H18 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9934522] NEXT:ZC3H18:CBCA:m7GpppN-RNA binds the RNA exosome - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-03-26
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9969603] Tong, Liang, 2025-10-23
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9934763
summation	[Summation:9935622] The NEXT complex is bound to the RNA cap via ZC3H18. The MTR...

Referrals

(hasEvent)

[Pathway:R-HSA-9930044] Nuclear RNA decay