Reactome | The RNA exosome in RNA exosome:NEXT:ZC3H18:CBCA:m7GpppN-RNA hydrolyzes RNA

The RNA exosome in RNA exosome:NEXT:ZC3H18:CBCA:m7GpppN-RNA hydrolyzes RNA

Stable Identifier

R-HSA-9934763

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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The RNA exosome in RNA exosome:NEXT:ZC3H18:CBCA:m7GpppN-RNA hydrolyzes RNA

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The NEXT complex is bound to the RNA cap via ZC3H18. The MTREX (MTR4, SKIV2L2) subunit of the NEXT complex recruits the RNA exosome (Lubas et al. 2011, Andersen et al. 2013) to hydrolyze substrate RNA by 3'-5' exonuclease activities of the DIS3 and EXOSC10 subunits of the RNA exosome (Liu et al. 2006, Januszyk et al. 2011, Weick et al. 2018, reviewed in Schmid and Jensen 2019, Ogami and Suzuki 2021). The RNA exosome degrades pervasive intergenic transcripts after the transcripts have dissociated from chromatin (Agostini et al. 2021).

Literature References

PubMed ID	Title	Journal	Year
21855801	Interaction profiling identifies the human nuclear exosome targeting complex Lubas, M, Christensen, MS, Kristiansen, MS, Domanski, M, Falkenby, LG, Lykke-Andersen, S, Andersen, JS, Dziembowski, A, Jensen, TH	Mol. Cell	2011
29906447	Helicase-Dependent RNA Decay Illuminated by a Cryo-EM Structure of a Human Nuclear RNA Exosome-MTR4 Complex Weick, EM, Puno, MR, Januszyk, K, Zinder, JC, DiMattia, MA, Lima, CD	Cell	2018
21705430	Activities of human RRP6 and structure of the human RRP6 catalytic domain Januszyk, K, Liu, Q, Lima, CD	RNA	2011
24270879	The human cap-binding complex is functionally connected to the nuclear RNA exosome Andersen, PR, Domanski, M, Kristiansen, MS, Storvall, H, Ntini, E, Verheggen, C, Schein, A, Bunkenborg, J, Poser, I, Hallais, M, Sandberg, R, Hyman, A, LaCava, J, Rout, MP, Andersen, JS, Bertrand, E, Jensen, TH	Nat Struct Mol Biol	2013
17174896	Reconstitution, activities, and structure of the eukaryotic RNA exosome Liu, Q, Greimann, JC, Lima, CD	Cell	2006
33952325	Intergenic RNA mainly derives from nascent transcripts of known genes Agostini, F, Zagalak, J, Attig, J, Ule, J, Luscombe, NM	Genome Biol	2021