Reactome | CDH1-associated CTNNA1 binds F-actin

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CDH1-associated CTNNA1 binds F-actin Show undefined attributes

authored	[InstanceEdit:9817331] Orlic-Milacic, Marija, 2022-09-15
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9934483] Orlic-Milacic, Marija, 2025-01-08
dbId	9934486
displayName	CDH1-associated CTNNA1 binds F-actin
edited	[InstanceEdit:9935645] Orlic-Milacic, Marija, 2025-01-17
eventOf	[Pathway:R-HSA-9958825] Activation of STAT3 by cadherin engagement - Homo sapiens [Pathway:R-HSA-9764561] Regulation of CDH1 Function - Homo sapiens
followingEvent	[Reaction:R-HSA-9934410] CDH1 forms homotypic trans-dimers - Homo sapiens [Reaction:R-HSA-9934294] CDH1-associated CTNNA1 binds VCL - Homo sapiens
input	5 × [Polymer:R-HSA-9913263] F-actin (all) [cytosol] [Complex:R-HSA-9934413] Homotypic CDH1 cis-cluster [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9934437] Actin-delimited adhesion-independent clustering of E-cadherin forms the nanoscale building blocks of adherens junctions [LiteratureReference:9934488] alpha-Catenin-vinculin interaction functions to organize the apical junctional complex in epithelial cells
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	CDH1-associated CTNNA1 binds F-actin
orthologousEvent	[Reaction:R-CEL-9934486] CDH1-associated CTNNA1 binds F-actin - Caenorhabditis elegans [Reaction:R-DME-9934486] CDH1-associated CTNNA1 binds F-actin - Drosophila melanogaster [Reaction:R-GGA-9934486] CDH1-associated CTNNA1 binds F-actin - Gallus gallus [Reaction:R-XTR-9934486] CDH1-associated CTNNA1 binds F-actin - Xenopus tropicalis [Reaction:R-DRE-9934486] CDH1-associated CTNNA1 binds F-actin - Danio rerio [Reaction:R-SSC-9934486] CDH1-associated CTNNA1 binds F-actin - Sus scrofa [Reaction:R-BTA-9934486] CDH1-associated CTNNA1 binds F-actin - Bos taurus [Reaction:R-CFA-9934486] CDH1-associated CTNNA1 binds F-actin - Canis familiaris [Reaction:R-RNO-9934486] CDH1-associated CTNNA1 binds F-actin - Rattus norvegicus [Reaction:R-MMU-9934486] CDH1-associated CTNNA1 binds F-actin - Mus musculus
output	[Complex:R-HSA-9934481] Homotypic CDH1 cis-cluster:F-actin [plasma membrane]
precedingEvent	[Reaction:R-HSA-9934411] CDH1 forms cis-clusters - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-06-18
releaseStatus	UPDATED
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9975417] Raptis, Leda, 2025-11-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9934486
summation	[Summation:9934484] CTNNA1 (?-catenin) is responsible for the recruitment of F-a...
updateTrackers	[UpdateTracker:9984630] Update Tracker - [Reaction:9934486] CDH1-associated CTNNA1 binds F-actin - v96:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9984630] Update Tracker - [Reaction:9934486] CDH1-associated CTNNA1 binds F-actin - v96:[modifyText]
(hasEvent)	[Pathway:R-HSA-9958825] Activation of STAT3 by cadherin engagement [Pathway:R-HSA-9764561] Regulation of CDH1 Function
(precedingEvent)	[Reaction:R-HSA-9934410] CDH1 forms homotypic trans-dimers [Reaction:R-HSA-9934294] CDH1-associated CTNNA1 binds VCL