Reactome | CDH1 forms cis-clusters

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CDH1 forms cis-clusters Show undefined attributes

authored	[InstanceEdit:9817331] Orlic-Milacic, Marija, 2022-09-15
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9934412] Orlic-Milacic, Marija, 2025-01-08
dbId	9934411
displayName	CDH1 forms cis-clusters
edited	[InstanceEdit:9935645] Orlic-Milacic, Marija, 2025-01-17
eventOf	[Pathway:R-HSA-9958825] Activation of STAT3 by cadherin engagement - Homo sapiens [Pathway:R-HSA-9764561] Regulation of CDH1 Function - Homo sapiens
followingEvent	[Reaction:R-HSA-9934486] CDH1-associated CTNNA1 binds F-actin - Homo sapiens
input	5 × [DefinedSet:R-HSA-9934398] Man,Man9GlucNAc2,p-3S-CDH1:CTNNB1,JUP:CTNNA1:CTNND1 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9762154] Adhesive but not lateral E-cadherin complexes require calcium and catenins for their formation [LiteratureReference:9934437] Actin-delimited adhesion-independent clustering of E-cadherin forms the nanoscale building blocks of adherens junctions
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	CDH1 forms cis-clusters
orthologousEvent	[Reaction:R-CEL-9934411] CDH1 forms cis-clusters - Caenorhabditis elegans [Reaction:R-DME-9934411] CDH1 forms cis-clusters - Drosophila melanogaster [Reaction:R-GGA-9934411] CDH1 forms cis-clusters - Gallus gallus [Reaction:R-XTR-9934411] CDH1 forms cis-clusters - Xenopus tropicalis [Reaction:R-DRE-9934411] CDH1 forms cis-clusters - Danio rerio [Reaction:R-SSC-9934411] CDH1 forms cis-clusters - Sus scrofa [Reaction:R-BTA-9934411] CDH1 forms cis-clusters - Bos taurus [Reaction:R-CFA-9934411] CDH1 forms cis-clusters - Canis familiaris [Reaction:R-RNO-9934411] CDH1 forms cis-clusters - Rattus norvegicus [Reaction:R-MMU-9934411] CDH1 forms cis-clusters - Mus musculus
output	[Complex:R-HSA-9934413] Homotypic CDH1 cis-cluster [plasma membrane]
precedingEvent	[Reaction:R-HSA-9817325] CDH1 associates with CTNND1 - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-06-18
releaseStatus	UPDATED
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9975417] Raptis, Leda, 2025-11-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9934411
summation	[Summation:9934430] CDH1 (E-cadherin) forms cis-homodimers/cis-homo-oligomers en...
updateTrackers	[UpdateTracker:9984722] Update Tracker - [Reaction:9934411] CDH1 forms cis-clusters - v96:[modifyText]

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(updatedInstance)	[UpdateTracker:9984722] Update Tracker - [Reaction:9934411] CDH1 forms cis-clusters - v96:[modifyText]
(hasEvent)	[Pathway:R-HSA-9958825] Activation of STAT3 by cadherin engagement [Pathway:R-HSA-9764561] Regulation of CDH1 Function
(precedingEvent)	[Reaction:R-HSA-9934486] CDH1-associated CTNNA1 binds F-actin