Reactome | RNA exosome in PAXT:PAPOLG:TENT4A,B:ZC3H3:CBCA:polyadenylated m7GpppN-RNA:PABPN1 hydrolyzes RNA

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RNA exosome in PAXT:PAPOLG:TENT4A,B:ZC3H3:CBCA:polyadenylated m7GpppN-RNA:PABPN1 hydrolyzes RNA Show undefined attributes

authored	[InstanceEdit:9930071] May, Bruce, 2024-12-01
catalystActivity	[CatalystActivity:9933569] 3'-5'-RNA exonuclease activity of PAXT:PAPOLG:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PAPBN1:RNA exosome [nucleoplasm]
category	uncertain
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9933586] May, Bruce, 2025-01-02
dbId	9933585
displayName	RNA exosome in PAXT:PAPOLG:TENT4A,B:ZC3H3:CBCA:polyadenylated m7GpppN-RNA:PABPN1 hydrolyzes RNA
edited	[InstanceEdit:9930071] May, Bruce, 2024-12-01
eventOf	[Pathway:R-HSA-9930044] Nuclear RNA decay - Homo sapiens
input	[Complex:R-HSA-9933591] PAXT:PAPOLG:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PAPBN1:RNA exosome [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9934093] A Two-Layered Targeting Mechanism Underlies Nuclear RNA Sorting by the Human Exosome [LiteratureReference:9934100] RNA 3'end tailing safeguards cells against products of pervasive transcription termination [LiteratureReference:9935627] Helicase-Dependent RNA Decay Illuminated by a Cryo-EM Structure of a Human Nuclear RNA Exosome-MTR4 Complex [LiteratureReference:9935634] Activities of human RRP6 and structure of the human RRP6 catalytic domain [LiteratureReference:433047] Reconstitution, activities, and structure of the eukaryotic RNA exosome [LiteratureReference:9933564] Identification of a Nuclear Exosome Decay Pathway for Processed Transcripts
maxDepth	1
modified	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
name	RNA exosome in PAXT:PAPOLG:TENT4A,B:ZC3H3:CBCA:polyadenylated m7GpppN-RNA:PABPN1 hydrolyzes RNA
orthologousEvent	[BlackBoxEvent:R-SSC-9933585] RNA exosome in PAXT:PAPOLG:TENT4A,B:ZC3H3:CBCA:polyadenylated m7GpppN-RNA:PABPN1 hydrolyzes RNA - Sus scrofa [BlackBoxEvent:R-CFA-9933585] RNA exosome in PAXT:PAPOLG:TENT4A,B:ZC3H3:CBCA:polyadenylated m7GpppN-RNA:PABPN1 hydrolyzes RNA - Canis familiaris [BlackBoxEvent:R-RNO-9933585] RNA exosome in PAXT:PAPOLG:TENT4A,B:ZC3H3:CBCA:polyadenylated m7GpppN-RNA:PABPN1 hydrolyzes RNA - Rattus norvegicus [BlackBoxEvent:R-MMU-9933585] RNA exosome in PAXT:PAPOLG:TENT4A,B:ZC3H3:CBCA:polyadenylated m7GpppN-RNA:PABPN1 hydrolyzes RNA - Mus musculus
output	[Complex:R-HSA-9930043] CBCA complex [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9934098] PAPOLG [nucleoplasm] [Complex:R-HSA-9930036] PAXT connection [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9935784] RBM26 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9935838] RBM27 [nucleoplasm] [Complex:R-HSA-9933578] RNA exosome [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9935812] YTHDC1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9935827] YTHDC2 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9933572] ZC3H3 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9933575] MTREX (MTR4, SKIV2L2) in PAXT:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PABPN1 binds the RNA exosome - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-03-26
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9969603] Tong, Liang, 2025-10-23
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9933585
summation	[Summation:9934081] The RNA exosome 3'-5' exonucleolytically hydrolyzes RNA (Liu...

Referrals

(hasEvent)

[Pathway:R-HSA-9930044] Nuclear RNA decay