Reactome | RNA exosome in PAXT:PAPOLG:TENT4A,B:ZC3H3:CBCA:polyadenylated m7GpppN-RNA:PABPN1 hydrolyzes RNA

RNA exosome in PAXT:PAPOLG:TENT4A,B:ZC3H3:CBCA:polyadenylated m7GpppN-RNA:PABPN1 hydrolyzes RNA

Stable Identifier

R-HSA-9933585

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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RNA exosome in PAXT:PAPOLG:TENT4A,B:ZC3H3:CBCA:polyadenylated m7GpppN-RNA:PABPN1 hydrolyzes RNA

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The RNA exosome 3'-5' exonucleolytically hydrolyzes RNA (Liu et al. 2006, Januszyk et al. 2011, Weick et al. 2018). The PAXT connection recruits the RNA exosome to degrade polyadenylated RNAs (Meola et al. 2016). RNAs that are normally targeted by the NEXT complex can become targeted to the PAXT connection if they are polyadenylated (Wu et al. 2020, Wu et al. 2024).

Literature References

PubMed ID	Title	Journal	Year
29906447	Helicase-Dependent RNA Decay Illuminated by a Cryo-EM Structure of a Human Nuclear RNA Exosome-MTR4 Complex Weick, EM, Puno, MR, Januszyk, K, Zinder, JC, DiMattia, MA, Lima, CD	Cell	2018
27871484	Identification of a Nuclear Exosome Decay Pathway for Processed Transcripts Meola, N, Domanski, M, Karadoulama, E, Chen, Y, Gentil, C, Pultz, D, Vitting-Seerup, K, Lykke-Andersen, S, Andersen, JS, Sandelin, A, Jensen, TH	Mol Cell	2016
32075771	A Two-Layered Targeting Mechanism Underlies Nuclear RNA Sorting by the Human Exosome Wu, G, Schmid, M, Rib, L, Polak, P, Meola, N, Sandelin, A, Jensen, TH	Cell Rep	2020
21705430	Activities of human RRP6 and structure of the human RRP6 catalytic domain Januszyk, K, Liu, Q, Lima, CD	RNA	2011
39617768	RNA 3'end tailing safeguards cells against products of pervasive transcription termination Wu, G, Rouvière, JO, Schmid, M, Heick Jensen, T	Nat Commun	2024
17174896	Reconstitution, activities, and structure of the eukaryotic RNA exosome Liu, Q, Greimann, JC, Lima, CD	Cell	2006