Reactome | MTREX (MTR4, SKIV2L2) in PAXT:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PABPN1 binds the RNA exosome

Schema > Reaction > Entries

MTREX (MTR4, SKIV2L2) in PAXT:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PABPN1 binds the RNA exosome Show undefined attributes

authored	[InstanceEdit:9930071] May, Bruce, 2024-12-01
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9933586] May, Bruce, 2025-01-02
dbId	9933575
displayName	MTREX (MTR4, SKIV2L2) in PAXT:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PABPN1 binds the RNA exosome
edited	[InstanceEdit:9930071] May, Bruce, 2024-12-01
eventOf	[Pathway:R-HSA-9930044] Nuclear RNA decay - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9933585] RNA exosome in PAXT:PAPOLG:TENT4A,B:ZC3H3:CBCA:polyadenylated m7GpppN-RNA:PABPN1 hydrolyzes RNA - Homo sapiens
input	[Complex:R-HSA-9933554] PAXT:PAPOLG:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PABPN1 [nucleoplasm] [Complex:R-HSA-9933578] RNA exosome [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9933568] Dual modes of ZFC3H1 confer selectivity in nuclear RNA sorting [LiteratureReference:9933564] Identification of a Nuclear Exosome Decay Pathway for Processed Transcripts [LiteratureReference:9933557] The human ZC3H3 and RBM26/27 proteins are critical for PAXT-mediated nuclear RNA decay [LiteratureReference:6791506] C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing
maxDepth	1
modified	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
name	MTREX (MTR4, SKIV2L2) in PAXT:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PABPN1 binds the RNA exosome
orthologousEvent	[Reaction:R-SPO-9933575] MTREX (MTR4, SKIV2L2) in PAXT:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PABPN1 binds the RNA exosome - Schizosaccharomyces pombe [Reaction:R-DDI-9933575] MTREX (MTR4, SKIV2L2) in PAXT:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PABPN1 binds the RNA exosome - Dictyostelium discoideum [Reaction:R-CEL-9933575] MTREX (MTR4, SKIV2L2) in PAXT:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PABPN1 binds the RNA exosome - Caenorhabditis elegans [Reaction:R-DME-9933575] MTREX (MTR4, SKIV2L2) in PAXT:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PABPN1 binds the RNA exosome - Drosophila melanogaster [Reaction:R-GGA-9933575] MTREX (MTR4, SKIV2L2) in PAXT:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PABPN1 binds the RNA exosome - Gallus gallus [Reaction:R-XTR-9933575] MTREX (MTR4, SKIV2L2) in PAXT:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PABPN1 binds the RNA exosome - Xenopus tropicalis [Reaction:R-DRE-9933575] MTREX (MTR4, SKIV2L2) in PAXT:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PABPN1 binds the RNA exosome - Danio rerio [Reaction:R-SSC-9933575] MTREX (MTR4, SKIV2L2) in PAXT:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PABPN1 binds the RNA exosome - Sus scrofa [Reaction:R-BTA-9933575] MTREX (MTR4, SKIV2L2) in PAXT:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PABPN1 binds the RNA exosome - Bos taurus [Reaction:R-CFA-9933575] MTREX (MTR4, SKIV2L2) in PAXT:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PABPN1 binds the RNA exosome - Canis familiaris [Reaction:R-RNO-9933575] MTREX (MTR4, SKIV2L2) in PAXT:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PABPN1 binds the RNA exosome - Rattus norvegicus [Reaction:R-MMU-9933575] MTREX (MTR4, SKIV2L2) in PAXT:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PABPN1 binds the RNA exosome - Mus musculus
output	[Complex:R-HSA-9933591] PAXT:PAPOLG:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PAPBN1:RNA exosome [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9933559] The PAXT connection (ZFC3H1:MTREX, ZFC3H1:MTR4), RBM26, RBM27, PAPOLG, YTHDC1, and YTHDC2 bind CBCA:polyadenylated m7GpppN-RNA:PABPN1 - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-03-26
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9969603] Tong, Liang, 2025-10-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9933575
summation	[Summation:9935790] The EXOSC10 (RRP6, PM/Scl-100) subunit of the RNA exosome as...

Referrals

(hasEvent)	[Pathway:R-HSA-9930044] Nuclear RNA decay
(precedingEvent)	[BlackBoxEvent:R-HSA-9933585] RNA exosome in PAXT:PAPOLG:TENT4A,B:ZC3H3:CBCA:polyadenylated m7GpppN-RNA:PABPN1 hydrolyzes RNA

Cite Us!