Reactome | The PAXT connection (ZFC3H1:MTREX, ZFC3H1:MTR4), RBM26, RBM27, PAPOLG, YTHDC1, and YTHDC2 bind CBCA:polyadenylated m7GpppN-RNA:PABPN1

Schema > Reaction > Entries

The PAXT connection (ZFC3H1:MTREX, ZFC3H1:MTR4), RBM26, RBM27, PAPOLG, YTHDC1, and YTHDC2 bind CBCA:polyadenylated m7GpppN-RNA:PABPN1 Show undefined attributes

authored	[InstanceEdit:9930071] May, Bruce, 2024-12-01
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9933586] May, Bruce, 2025-01-02
dbId	9933559
displayName	The PAXT connection (ZFC3H1:MTREX, ZFC3H1:MTR4), RBM26, RBM27, PAPOLG, YTHDC1, and YTHDC2 bind CBCA:polyadenylated m7GpppN-RNA:PABPN1
edited	[InstanceEdit:9930071] May, Bruce, 2024-12-01
eventOf	[Pathway:R-HSA-9930044] Nuclear RNA decay - Homo sapiens
followingEvent	[Reaction:R-HSA-9933575] MTREX (MTR4, SKIV2L2) in PAXT:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PABPN1 binds the RNA exosome - Homo sapiens
input	[Complex:R-HSA-9935798] CBCA:ZFC3H1:polyadenylated m7GpppN-RNA:PABPN1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9934098] PAPOLG [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9935784] RBM26 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9935838] RBM27 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-6791189] SKIV2L2 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9935812] YTHDC1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9935827] YTHDC2 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9933572] ZC3H3 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9933568] Dual modes of ZFC3H1 confer selectivity in nuclear RNA sorting [LiteratureReference:9933564] Identification of a Nuclear Exosome Decay Pathway for Processed Transcripts [LiteratureReference:9933587] Dual agonistic and antagonistic roles of ZC3H18 provide for co-activation of distinct nuclear RNA decay pathways [LiteratureReference:9933557] The human ZC3H3 and RBM26/27 proteins are critical for PAXT-mediated nuclear RNA decay [LiteratureReference:9934077] PAP? associates with PAXT nuclear exosome to control the abundance of PROMPT ncRNAs
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	The PAXT connection (ZFC3H1:MTREX, ZFC3H1:MTR4), RBM26, RBM27, PAPOLG, YTHDC1, and YTHDC2 bind CBCA:polyadenylated m7GpppN-RNA:PABPN1
orthologousEvent	[Reaction:R-DME-9933559] The PAXT connection (ZFC3H1:MTREX, ZFC3H1:MTR4), RBM26, RBM27, PAPOLG, YTHDC1, and YTHDC2 bind CBCA:polyadenylated m7GpppN-RNA:PABPN1 - Drosophila melanogaster [Reaction:R-SSC-9933559] The PAXT connection (ZFC3H1:MTREX, ZFC3H1:MTR4), RBM26, RBM27, PAPOLG, YTHDC1, and YTHDC2 bind CBCA:polyadenylated m7GpppN-RNA:PABPN1 - Sus scrofa [Reaction:R-CFA-9933559] The PAXT connection (ZFC3H1:MTREX, ZFC3H1:MTR4), RBM26, RBM27, PAPOLG, YTHDC1, and YTHDC2 bind CBCA:polyadenylated m7GpppN-RNA:PABPN1 - Canis familiaris [Reaction:R-RNO-9933559] The PAXT connection (ZFC3H1:MTREX, ZFC3H1:MTR4), RBM26, RBM27, PAPOLG, YTHDC1, and YTHDC2 bind CBCA:polyadenylated m7GpppN-RNA:PABPN1 - Rattus norvegicus [Reaction:R-MMU-9933559] The PAXT connection (ZFC3H1:MTREX, ZFC3H1:MTR4), RBM26, RBM27, PAPOLG, YTHDC1, and YTHDC2 bind CBCA:polyadenylated m7GpppN-RNA:PABPN1 - Mus musculus
output	[Complex:R-HSA-9933554] PAXT:PAPOLG:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PABPN1 [nucleoplasm]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-03-26
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9969603] Tong, Liang, 2025-10-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9933559
summation	[Summation:9933583] During RNA transcription, ZFC3H1 binds the first exon and fi...

Referrals

(precedingEvent)	[Reaction:R-HSA-9933575] MTREX (MTR4, SKIV2L2) in PAXT:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PABPN1 binds the RNA exosome
(hasEvent)	[Pathway:R-HSA-9930044] Nuclear RNA decay

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