Reactome | TFPI? + FV intermediate + PROS1 => TFPI?:FV intermediate:PROS1

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TFPI? + FV intermediate + PROS1 => TFPI?:FV intermediate:PROS1 Show undefined attributes

authored	[InstanceEdit:9929032] Shamovsky, Veronica, 2024-11-20
category	binding
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:9931616] Shamovsky, Veronica, 2024-12-12
dbId	9931628
displayName	TFPI? + FV intermediate + PROS1 => TFPI?:FV intermediate:PROS1
edited	[InstanceEdit:9937613] Shamovsky, Veronica, 2025-02-05
eventOf	[Pathway:R-HSA-9769739] Regulation of clotting cascade - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-202772] 11xCbxE-PROS1 [extracellular region] [Complex:R-HSA-9930795] factor Va intermediate [extracellular region] [EntityWithAccessionedSequence:R-HSA-9931632] TFPI? [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9935087] Factor V-short and protein S as synergistic tissue factor pathway inhibitor (TFPI?) cofactors [LiteratureReference:9935090] Protein S stimulates inhibition of the tissue factor pathway by tissue factor pathway inhibitor [LiteratureReference:9931614] Comparison of cell-surface TFPIalpha and beta [LiteratureReference:9931646] Cellular expression and biological activities of alternatively spliced forms of tissue factor pathway inhibitor [LiteratureReference:140829] Regulation of coagulation by a multivalent Kunitz-type inhibitor [LiteratureReference:9931647] Biology of tissue factor pathway inhibitor
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	TFPI? + FV intermediate + PROS1 => TFPI?:FV intermediate:PROS1 TFPI? binds FV intermediate and protein S
orthologousEvent	[Reaction:R-GGA-9931628] TFPI? + FV intermediate + PROS1 => TFPI?:FV intermediate:PROS1 - Gallus gallus [Reaction:R-SSC-9931628] TFPI? + FV intermediate + PROS1 => TFPI?:FV intermediate:PROS1 - Sus scrofa [Reaction:R-BTA-9931628] TFPI? + FV intermediate + PROS1 => TFPI?:FV intermediate:PROS1 - Bos taurus [Reaction:R-CFA-9931628] TFPI? + FV intermediate + PROS1 => TFPI?:FV intermediate:PROS1 - Canis familiaris [Reaction:R-MMU-9931628] TFPI? + FV intermediate + PROS1 => TFPI?:FV intermediate:PROS1 - Mus musculus
output	[Complex:R-HSA-9931610] TFPI?:FV intermediate:PROS1 [extracellular region]
precedingEvent	[Reaction:R-HSA-9769737] factor V -> factor Va intermediate + factor V activation peptide (FXa catalyst) - Homo sapiens [Reaction:R-HSA-9930790] factor V -> factor Va intermediate + factor V activation peptide (thrombin catalyst) - Homo sapiens [Reaction:R-HSA-481007] Exocytosis of platelet alpha granule contents - Homo sapiens
releaseDate	2026-03-25
releaseStatus	NEW
reviewStatus	[ReviewStatus:9821383] three stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9931628
summation	[Summation:9931651] This Reactome event shows the formation of the trimolecular ...

Referrals

(hasEvent)

[Pathway:R-HSA-9769739] Regulation of clotting cascade