Reactome | CD274 translation

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CD274 translation Show undefined attributes

authored	[InstanceEdit:9964122] Hung, Mien-Chie, Yamaguchi, Hirohito, 2025-08-26 [InstanceEdit:9927358] Tiwari, Krishna, 2024-11-05
category	uncertain
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9925315] Tiwari, Krishna, 2024-10-16
dbId	9925190
displayName	CD274 translation
edited	[InstanceEdit:9962761] Gillespie, Marc E, 2025-08-08
eventOf	[Pathway:R-HSA-9909620] Regulation of PD-L1(CD274) translation - Homo sapiens
followingEvent	[Reaction:R-HSA-9931290] IL6-activated JAK1 phosphorylates CD274 - Homo sapiens [Reaction:R-HSA-9929360] GSK3B phosphorylates CD274 - Homo sapiens [Reaction:R-HSA-9931409] NEK2 phosphorylates CD274 - Homo sapiens [Reaction:R-HSA-9931292] AMPK phosphorylates CD274 - Homo sapiens [Reaction:R-HSA-9931418] CK2 phosphorylates CD274 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-9909617] CD274 mRNA [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9912819] Immunomodulatory role for MicroRNAs: Regulation of PD-1/PD-L1 and CTLA-4 immune checkpoints expression [LiteratureReference:9912804] The Roles of microRNAs in Regulating the Expression of PD-1/PD-L1 Immune Checkpoint [LiteratureReference:9924898] How microRNAs affect the PD-L1 and its synthetic pathway in cancer [LiteratureReference:9925184] Tumor Suppressor microRNAs Contribute to the Regulation of PD-L1 Expression in Malignant Pleural�Mesothelioma [LiteratureReference:9924891] New Dancing Couple: PD-L1 and MicroRNA
maxDepth	1
modified	[InstanceEdit:9965199] Matthews, Lisa, 2025-08-26
name	CD274 translation
output	[EntityWithAccessionedSequence:R-HSA-9930703] CD274 [endoplasmic reticulum membrane]
precedingEvent	[BlackBoxEvent:R-HSA-9909623] CD274 Transcription - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
regulatedBy	[NegativeRegulation:9924958] Negative regulation by 'CD274:miR-200B/C RISC [cytosol]' [NegativeRegulation:9925033] Negative regulation by 'CD274 mRNA:miR-34 RISC [cytosol]' [NegativeRegulation:9924998] Negative regulation by 'CD274 mRNA:miR140 RISC [cytosol]' [NegativeRegulation:9925283] Negative regulation by 'CD274 mRNA:miR-142-5p RISC [cytosol]' [NegativeRegulation:9924992] Negative regulation by 'CD274 mRNA:miR-148a-3p RISC [cytosol]' [NegativeRegulation:9925052] Negative regulation by 'CD274 mRNA:miR-152 RISC [cytosol]' [NegativeRegulation:9925101] Negative regulation by 'CD274 mRNA:miR-let7-a1 RISC [cytosol]' [NegativeRegulation:9925344] Negative regulation by 'CD274 mRNA:miR-340 RISC [cytosol]' [NegativeRegulation:9924910] Negative regulation by 'CD274 mRNA:miR-93 RISC [cytosol]' [NegativeRegulation:9925029] Negative regulation by 'CD274 mRNA:miR424 RISC [cytosol]' [NegativeRegulation:9924956] Negative regulation by 'CD274 mRNA:miR-429 RISC [cytosol]' [NegativeRegulation:9925064] Negative regulation by 'CD274 mRNA:miR-138-5p RISC [cytosol]'
regulationReference	[RegulationReference:9925164] Negative regulation by 'CD274:miR-200B/C RISC [cytosol]' Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression [RegulationReference:9925248] Negative regulation by 'CD274 mRNA:miR-34 RISC [cytosol]' Tumor suppressor miR-34a targets PD-L1 and functions as a potential immunotherapeutic target in acute myeloid leukemia [RegulationReference:9925187] Negative regulation by 'CD274 mRNA:miR140 RISC [cytosol]' MiR-140 Expression Regulates Cell Proliferation and Targets PD-L1 in NSCLC [RegulationReference:9924935] Negative regulation by 'CD274 mRNA:miR-142-5p RISC [cytosol]' Correction: Control of PD-L1 expression by miR-140/142/340/383 and oncogenic activation of the OCT4-miR-18a pathway in cervical cancer [RegulationReference:9925291] Negative regulation by 'CD274 mRNA:miR-148a-3p RISC [cytosol]' miRNA-148a-3p Regulates Immunosuppression in DNA Mismatch Repair-Deficient Colorectal Cancer by Targeting PD-L1 [RegulationReference:9925191] Negative regulation by 'CD274 mRNA:miR-152 RISC [cytosol]' MicroRNA-152 regulates immune response via targeting B7-H1 in gastric carcinoma [RegulationReference:9925181] Negative regulation by 'CD274 mRNA:miR-let7-a1 RISC [cytosol]' LIN28/let-7/PD-L1 Pathway as a Target for Cancer Immunotherapy [RegulationReference:9925170] Negative regulation by 'CD274 mRNA:miR-340 RISC [cytosol]' Correction: Control of PD-L1 expression by miR-140/142/340/383 and oncogenic activation of the OCT4-miR-18a pathway in cervical cancer [RegulationReference:9924959] Negative regulation by 'CD274 mRNA:miR-93 RISC [cytosol]' MiR-93-5p regulates tumorigenesis and tumor immunity by targeting PD-L1/CCND1 in breast cancer [RegulationReference:9925163] Negative regulation by 'CD274 mRNA:miR424 RISC [cytosol]' miR-424(322) reverses chemoresistance via T-cell immune response activation by blocking the PD-L1 immune checkpoint [RegulationReference:9925113] Negative regulation by 'CD274 mRNA:miR-429 RISC [cytosol]' PD-L1 Under Regulation of miR-429 Influences the Sensitivity of Gastric Cancer Cells to TRAIL by Binding of EGFR [RegulationReference:9925054] Negative regulation by 'CD274 mRNA:miR-138-5p RISC [cytosol]' PDL1 targeting by miR-138-5p amplifies anti-tumor immunity and Jurkat cells survival in non-small cell lung cancer
releaseDate	2025-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9964122] Hung, Mien-Chie, Yamaguchi, Hirohito, 2025-08-26
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9925190
summation	[Summation:9925203] CD274 (PD-L1) translation is a critical step in the regulati...

Referrals

(precedingEvent)	[Reaction:R-HSA-9931290] IL6-activated JAK1 phosphorylates CD274 [Reaction:R-HSA-9929360] GSK3B phosphorylates CD274 [Reaction:R-HSA-9931409] NEK2 phosphorylates CD274 [Reaction:R-HSA-9931292] AMPK phosphorylates CD274 [Reaction:R-HSA-9931418] CK2 phosphorylates CD274
(hasEvent)	[Pathway:R-HSA-9909620] Regulation of PD-L1(CD274) translation

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