Reactome | FecBCDE imports Fe3+-citrates to cytosol

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FecBCDE imports Fe3+-citrates to cytosol Show undefined attributes

authored	[InstanceEdit:9931008] Stephan, Ralf, 2024-12-08
catalystActivity	[CatalystActivity:9931028] iron chelate transmembrane transporter activity of FecBCDE [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9931029] Stephan, Ralf, 2024-12-09
crossReference	[DatabaseIdentifier:12020761] Mondo:0005113
dbId	9931048
disease	[Disease:3134792] bacterial infectious disease
displayName	FecBCDE imports Fe3+-citrates to cytosol
edited	[InstanceEdit:9948470] Stephan, Ralf, 2025-05-21
eventOf	[Pathway:R-HSA-9638482] Metal ion assimilation from the host - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [DefinedSet:R-ALL-9931051] Fe3+-citrates [periplasmic space]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9931027] Nucleotide sequences of the fecBCDE genes and locations of the proteins suggest a periplasmic-binding-protein-dependent transport mechanism for iron(III) dicitrate in Escherichia coli [LiteratureReference:9638421] Docking of the periplasmic FecB binding protein to the FecCD transmembrane proteins in the ferric citrate transport system of Escherichia coli [LiteratureReference:9931014] FecB, a periplasmic ferric-citrate transporter from E. coli, can bind different forms of ferric-citrate as well as a wide variety of metal-free and metal-loaded tricarboxylic acids
maxDepth	1
modified	[InstanceEdit:9948469] Stephan, Ralf, 2025-05-21
name	FecBCDE imports Fe3+-citrates to cytosol
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [DefinedSet:R-ALL-9931015] Fe3+-citrates [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-HSA-9931043] FecA:TonB:ExbB:ExbD imports Fe3+-citrates to periplasm - Homo sapiens
relatedSpecies	[Species:159879] Escherichia coli
releaseDate	2025-06-18
reviewStatus	[ReviewStatus:9821383] three stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9931048
summation	[Summation:9931049] E.coli ABC transporter complex FecBCDE imports Fe3+-citrates...

Referrals

(hasEvent)

[Pathway:R-HSA-9638482] Metal ion assimilation from the host

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