Reactome | ChuA imports heme to periplasm

Schema > Reaction > Entries

ChuA imports heme to periplasm Show undefined attributes

authored	[InstanceEdit:9927214] Stephan, Ralf, 2024-11-05
catalystActivity	[CatalystActivity:9927217] heme transmembrane transporter activity of ChuA:TonB:ExbB:ExbD [cell outer membrane]
category	transition
compartment	[Compartment:20798] cell outer membrane [Compartment:1222638] periplasmic space [Compartment:876] plasma membrane
created	[InstanceEdit:9927223] Stephan, Ralf, 2024-11-05
crossReference	[DatabaseIdentifier:12020761] Mondo:0005113 [DatabaseIdentifier:9961768] UniProt:A0A0H2V8J2
dbId	9927224
deleted	[Deleted:9964264] Deletion of instance: 9927481 [Deleted:9961772] Deletion of instance: 9927481 [Deleted:9964557] Deletion of instance: 9927481
disease	[Disease:3134792] bacterial infectious disease
displayName	ChuA imports heme to periplasm
edited	[InstanceEdit:9948470] Stephan, Ralf, 2025-05-21
eventOf	[Pathway:R-HSA-9927020] Heme assimilation - Homo sapiens
followingEvent	[Reaction:R-HSA-9927609] PBP binds heme - Homo sapiens
input	[SimpleEntity:R-ALL-8858135] H+ [periplasmic space] [SimpleEntity:R-ALL-917877] heme [extracellular region]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9927218] Haem iron-transport system in enterohaemorrhagic Escherichia coli O157:H7 [LiteratureReference:9927229] TonB-dependent systems of uropathogenic Escherichia coli: aerobactin and heme transport and TonB are required for virulence in the mouse [LiteratureReference:9638477] Metal selectivity by the virulence-associated yersiniabactin metallophore system [LiteratureReference:9927480] Structural and functional diversity of transient heme binding to bacterial proteins [LiteratureReference:9927475] Haem acquisition is facilitated by a novel receptor Hma and required by uropathogenic Escherichia coli for kidney infection
maxDepth	1
modified	[InstanceEdit:9961769] Stephan, Ralf, 2025-07-26
name	ChuA imports heme to periplasm
output	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-9927227] heme [periplasmic space]
precedingEvent	[BlackBoxEvent:R-HSA-9926936] EspC(54-1018) cleaves hemoglobin - Homo sapiens [BlackBoxEvent:R-HSA-9927009] Hbp(53-1100) cleaves hemoglobin - Homo sapiens
relatedSpecies	[Species:159879] Escherichia coli
releaseDate	2025-06-18
reviewStatus	[ReviewStatus:9821383] three stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9927224
summation	[Summation:9927608] The ChuA receptor of pathogenic E.coli (UPEC) imports heme t...
updateTrackers	[UpdateTracker:9964707] Update Tracker - [Reaction:9927224] ChuA imports heme to periplasm - v94:[modifyText, removeLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9964707] Update Tracker - [Reaction:9927224] ChuA imports heme to periplasm - v94:[modifyText, removeLiteratureReference]
(replacementInstances)	[Deleted:9964264] Deletion of instance: 9927481 [Deleted:9961772] Deletion of instance: 9927481 [Deleted:9964557] Deletion of instance: 9927481
(hasEvent)	[Pathway:R-HSA-9927020] Heme assimilation
(precedingEvent)	[Reaction:R-HSA-9927609] PBP binds heme