Reactome | MITF-M binds CREBBP,EP300

MITF-M binds CREBBP,EP300

Stable Identifier

R-HSA-9926478

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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MITF-M interacts with CREBBP and EP300 to activate expression at target genes (Sato et al, 1997; Brown et al, 2023 a,b). Interaction is mediated by two transactivation domains (TAD) in MITF-M, one at the N-terminal and one in the disordered C-terminal region ((Sato et al, 1997; Brown et al, 2023 a,b). Both regions of MITF-M interact with the TAZ1 and TAZ2 domains of the histone acetyltransferases (Brown et al, 2023 a,b). Some studies have shown that the interaction between MITF and CREBBP and EP300 is enhanced by MAPK1-dependent phosphorylation of MITF-M at serine 73, however other studies have not reproduced this effect (Price et al, 1998; Xu et al, 2000; Sato et al, 1997)

Literature References

PubMed ID	Title	Journal	Year
37752231	The C-terminal transactivation domain of MITF interacts promiscuously with co-activator CBP/p300 Brown, AD, Lynch, K, Langelaan, DN	Sci Rep	2023
9223672	CBP/p300 as a co-factor for the Microphthalmia transcription factor Sato, S, Roberts, K, Gambino, G, Cook, A, Kouzarides, T, Goding, CR	Oncogene	1997
10673502	c-Kit triggers dual phosphorylations, which couple activation and degradation of the essential melanocyte factor Mi Wu, M, Hemesath, TJ, Takemoto, CM, Horstmann, MA, Wells, AG, Price, ER, Fisher, DZ, Fisher, DE	Genes Dev	2000
9660747	Lineage-specific signaling in melanocytes. C-kit stimulation recruits p300/CBP to microphthalmia Price, ER, Ding, HF, Badalian, T, Bhattacharya, S, Takemoto, C, Yao, TP, Hemesath, TJ, Fisher, DE	J Biol Chem	1998
37353163	Structural basis of CBP/p300 recruitment by the microphthalmia-associated transcription factor Brown, AD, Vergunst, KL, Branch, M, Blair, CM, Dupré, DJ, Baillie, GS, Langelaan, DN	Biochim Biophys Acta Mol Cell Res	2023