Reactome | HlyB:HlyD:TolC transports HlyA from periplasm to extracellular space

Schema > Reaction > Entries

HlyB:HlyD:TolC transports HlyA from periplasm to extracellular space Show undefined attributes

authored	[InstanceEdit:9926023] Stephan, Ralf, 2024-10-30
catalystActivity	[CatalystActivity:9926034] porin activity of HlyB:HlyD:TolC [cell outer membrane]
category	transition
compartment	[Compartment:1222638] periplasmic space [Compartment:20798] cell outer membrane [Compartment:984] extracellular region
created	[InstanceEdit:9926031] Stephan, Ralf, 2024-10-30
crossReference	[DatabaseIdentifier:12020761] Mondo:0005113
dbId	9926021
disease	[Disease:3134792] bacterial infectious disease
displayName	HlyB:HlyD:TolC transports HlyA from periplasm to extracellular space
edited	[InstanceEdit:9948470] Stephan, Ralf, 2025-05-21
eventOf	[Pathway:R-HSA-9760173] Secretion of toxins - Homo sapiens
input	[DefinedSet:R-ECO-9926028] HlyA [periplasmic space]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9926096] Nucleotide sequence of an Escherichia coli chromosomal hemolysin [LiteratureReference:9926097] HlyB-dependent secretion of hemolysin by uropathogenic Escherichia coli requires conserved sequences flanking the chromosomal hly determinant [LiteratureReference:9926098] Effects of Escherichia coli hemolysin on endothelial cell function [LiteratureReference:9926114] Enterobacterial hemolysins: activation, secretion and pore formation [LiteratureReference:9926093] In vivo and in vitro studies on interactions between the components of the hemolysin (HlyA) secretion machinery of Escherichia coli [LiteratureReference:9911195] Structure, Assembly, and Function of Tripartite Efflux and Type 1 Secretion Systems in Gram-Negative Bacteria
maxDepth	1
modified	[InstanceEdit:9948469] Stephan, Ralf, 2025-05-21
name	HlyB:HlyD:TolC transports HlyA from periplasm to extracellular space
output	[DefinedSet:R-ECO-9926037] HlyA [extracellular region]
precedingEvent	[Reaction:R-HSA-9926041] HlyB:HlyD:TolC transports HlyA from cytosol to periplasm - Homo sapiens
relatedSpecies	[Species:159879] Escherichia coli
releaseDate	2025-06-18
reviewStatus	[ReviewStatus:9821383] three stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9926021
summation	[Summation:9926112] E. coli strains causing extraintestinal infections secrete ?...

Referrals

(hasEvent)

[Pathway:R-HSA-9760173] Secretion of toxins

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