Reactome | CD274 mRNA binds miR-34 RISC

Schema > Reaction > Entries

authored	[InstanceEdit:9964122] Hung, Mien-Chie, Yamaguchi, Hirohito, 2025-08-26 [InstanceEdit:9927358] Tiwari, Krishna, 2024-11-05
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9925315] Tiwari, Krishna, 2024-10-16
dbId	9924921
displayName	CD274 mRNA binds miR-34 RISC
edited	[InstanceEdit:9962761] Gillespie, Marc E, 2025-08-08
eventOf	[Pathway:R-HSA-9909620] Regulation of PD-L1(CD274) translation - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-9909617] CD274 mRNA [cytosol] [DefinedSet:R-HSA-1606685] miR-34 RISC [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9925014] Tumor suppressor miR-34a targets PD-L1 and functions as a potential immunotherapeutic target in acute myeloid leukemia [LiteratureReference:9924967] MiR-34a suppresses the proliferation and invasion of gastric cancer by modulating PDL1 in the immune microenvironment
maxDepth	1
modified	[InstanceEdit:9965199] Matthews, Lisa, 2025-08-26
name	CD274 mRNA binds miR-34 RISC
output	[Complex:R-HSA-9925250] CD274 mRNA:miR-34 RISC [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-9909623] CD274 Transcription - Homo sapiens
releaseDate	2025-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9964122] Hung, Mien-Chie, Yamaguchi, Hirohito, 2025-08-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9924921
summation	[Summation:9924885] MicroRNA-34a (miR-34a), a central regulator within the T cel...

(hasEvent)

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