Reactome | MicroRNA-34a (miR-34a), a central regulator within the T cel...

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created	[InstanceEdit:9925315] Tiwari, Krishna, 2024-10-16
dbId	9924885
displayName	MicroRNA-34a (miR-34a), a central regulator within the T cel...
literatureReference	[LiteratureReference:9924863] Regulatory and immunomodulatory role of miR-34a in T cell immunity [LiteratureReference:9925014] Tumor suppressor miR-34a targets PD-L1 and functions as a potential immunotherapeutic target in acute myeloid leukemia [LiteratureReference:9924967] MiR-34a suppresses the proliferation and invasion of gastric cancer by modulating PDL1 in the immune microenvironment
modified	[InstanceEdit:9925973] Tiwari, Krishna, 2024-10-29
schemaClass	Summation
text	MicroRNA-34a (miR-34a), a central regulator within the T cell regulatory network, plays a crucial role in T cell activation. It is broadly expressed across immune cell types, including dendritic cells, macrophages, mast cells, B cells, and T cells, where it influences their development, function, and survival (Taheri et al., 2020). In relation to PD-L1 regulation, miR-34a directly targets the 3' UTR of PD-L1 mRNA. This was demonstrated through a luciferase assay using HL-60 and Kasumi-1 cell lines, where co-transfection with miR-34a resulted in reduced reporter activity, confirming its binding to PD-L1 and subsequent suppression of its expression. Moreover, miR-34a overexpression led to reduced PD-L1 surface levels and decreased T-cell apoptosis (Wang et al., 2015; Yong et al., 2020).

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