Reactome | p-S-CRY:p-S-PER:CSNK1D,E:p-S90,Ac-538-BMAL1:p-4S,2T-CLOCK dissociates from target gene

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p-S-CRY:p-S-PER:CSNK1D,E:p-S90,Ac-538-BMAL1:p-4S,2T-CLOCK dissociates from target gene Show undefined attributes

authored	[InstanceEdit:9923004] May, Bruce, 2024-09-21
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9922979] May, Bruce, 2024-09-29
dbId	9923005
displayName	p-S-CRY:p-S-PER:CSNK1D,E:p-S90,Ac-538-BMAL1:p-4S,2T-CLOCK dissociates from target gene
edited	[InstanceEdit:9923004] May, Bruce, 2024-09-21
eventOf	[Pathway:R-HSA-9931521] The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9932512] FBXL3:CUL1:SKP1:RBX1 ubiquitinylates phosphorylated CRY1,2 - Homo sapiens
inferredFrom	[Reaction:R-MMU-9927991] p-S-Cry:p-S-Per:Csnk1d,e:p-S90,Ac-538-Bmal1:p-4S,2T-Clock dissociates from target gene - Mus musculus
input	[Complex:R-HSA-9922278] p-S-CRY:p-S-PER:CSNK1D,E:p-S90,Ac-K538-BMAL1:p-4S,2T-CLOCK:target gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
maxDepth	1
modified	[InstanceEdit:9939305] May, Bruce, 2025-02-24
name	p-S-CRY:p-S-PER:CSNK1D,E:p-S90,Ac-538-BMAL1:p-4S,2T-CLOCK dissociates from target gene
output	[Complex:R-HSA-9922975] p-S-CRY:p-S-PER:CSNK1D,E:p-S90,Ac-K538-BMAL1:p-4S,2T-CLOCK [nucleoplasm] [DefinedSet:R-HSA-9923019] Target gene of BMAL1:CLOCK [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9922273] CSNK1D,E phosphorylates CLOCK in p-S-CRY:p-S-PER:CSNK1D,E:p-S90,Ac-538-BMAL:p-2T,3S-CLOCK:target gene - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-03-26
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9938389] Sancar, Aziz, 2025-02-14 [InstanceEdit:9938694] Albrecht, Urs, 2025-02-18
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9923005
summation	[Summation:9931523] After phosphorylation of CLOCK by the kinase CSNK1D, the BMA...

Referrals

(precedingEvent)	[BlackBoxEvent:R-HSA-9932512] FBXL3:CUL1:SKP1:RBX1 ubiquitinylates phosphorylated CRY1,2
(hasEvent)	[Pathway:R-HSA-9931521] The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex
(inferredTo)	[Reaction:R-MMU-9927991] p-S-Cry:p-S-Per:Csnk1d,e:p-S90,Ac-538-Bmal1:p-4S,2T-Clock dissociates from target gene

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