p-S-CRY:p-S-PER:CSNK1D,E:p-S90,Ac-538-BMAL1:p-4S,2T-CLOCK dissociates from target gene

Stable Identifier
R-HSA-9923005
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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p-S-CRY:p-S-PER:CSNK1D,E:p-S90,Ac-538-BMAL1:p-4S,2T-CLOCK dissociates from target gene
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After phosphorylation of CLOCK by the kinase CSNK1D, the BMAL1:CLOCK heterodimer dissociates from DNA (inferred from mouse homologs). CRY and PER proteins form a complex with CSNK1D, shuttle CSNK1D into the nucleus, and bring CSNK1D into proximity with CLOCK (inferred from mouse homologs). CSNK1E appears to act redundantly with CSNK1D. Notably, after BMAL1:CLOCK dissociates from promoters, some promoters are negatively regulated and some promoters, such as the CRY1 promoter, are positively regulated by residual PER proteins (inferred from mouse homologs in Chiou et al. 2016).
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p-S-Cry:p-S-Per:Csnk1d,e:p-S90,Ac-538-Bmal1:p-4S,2T-Clock dissociates from target gene (Mus musculus)
Authored
May, B  (2024-09-21)
Reviewed
Sancar, A  (2025-02-14)
Albrecht, U  (2025-02-18)
Created
May, B  (2024-09-29)
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