NS1 binds TLR4

Stable Identifier
R-HSA-9921458
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Dengue virus type 2
Compartment
plasma membrane
ReviewStatus
5/5
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NS1 binds TLR4
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Secreted Dengue virus (DENV) NS1 protein, primarily from DENV-2 but also demonstrated with other serotypes, binds and activates the TLR4 receptor on human and mouse platelets and immune cells. This activation induces cytokine production and contributes to severe manifestations of Dengue virus disease, such as vascular leak, thrombocytopenia, and hemorrhage (Modhiran et al., 2015; Modhiran et al., 2017; Chao et al., 2019).
Literature References
PubMed ID Title Journal Year
26355031 Dengue virus NS1 protein activates cells via Toll-like receptor 4 and disrupts endothelial cell monolayer integrity

Modhiran, N, Watterson, D, Muller, DA, Panetta, AK, Sester, DP, Liu, L, Hume, DA, Stacey, KJ, Young, PR

Sci Transl Med 2015
31009511 Dengue virus nonstructural protein 1 activates platelets via Toll-like receptor 4, leading to thrombocytopenia and hemorrhage

Chao, CH, Wu, WC, Lai, YC, Tsai, PJ, Perng, GC, Lin, YS, Yeh, TM

PLoS Pathog 2019
28220810 Dengue virus NS1 protein activates immune cells via TLR4 but not TLR2 or TLR6

Modhiran, N, Watterson, D, Blumenthal, A, Baxter, AG, Young, PR, Stacey, KJ

Immunol Cell Biol 2017
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
dengue disease DOID:12205 breakbone fever, Dengue Fever, classic dengue
Cross References
Mondo
Authored
Stephan, R  (2024-09-09)
Reviewed
Roque Ascenção, F  (2025-10-29)
Mansur, DS  (2025-10-29)
Created
Stephan, R  (2024-09-10)
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