Secreted NS1 binds to HDL

Stable Identifier
R-HSA-9920071
Type
Reaction [omitted]
Species
Homo sapiens
Related Species
Dengue virus type 2
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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Secreted NS1 binds to HDL
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After localizing to the cell membrane, NS1 exists as a hydrophobic dimer (Pryor & Wright, 1994; reviewed in Carpio & Barrett, 2021). Secreted NS1 forms complexes of NS1 dimers with HDL particles, through interaction with the ApoA1 component (Benfrid et al., 2022; Chew et al., 2024).
Literature References
PubMed ID Title Journal Year
38787378 Secreted dengue virus NS1 from infection is predominantly dimeric and in complex with high-density lipoprotein

Chew, BLA, Ngoh, ANQ, Phoo, WW, Chan, KWK, Ser, Z, Tulsian, NK, Lim, SS, Weng, MJG, Watanabe, S, Choy, MM, Low, J, Ooi, EE, Ruedl, C, Sobota, RM, Vasudevan, SG, Luo, D

Elife 2024
35607830 Dengue virus NS1 protein conveys pro-inflammatory signals by docking onto high-density lipoproteins

Benfrid, S, Park, KH, Dellarole, M, Voss, JE, Tamietti, C, Pehau-Arnaudet, G, Raynal, B, Brûlé, S, England, P, Zhang, X, Mikhailova, A, Hasan, M, Ungeheuer, MN, Petres, S, Biering, SB, Harris, E, Sakuntabhai, A, Buchy, P, Duong, V, Dussart, P, Coulibaly, F, Bontems, F, Rey, FA, Flamand, M

EMBO Rep 2022
8176380 Glycosylation mutants of dengue virus NS1 protein

Pryor, MJ, Wright, PJ

J Gen Virol 1994
34207516 Flavivirus NS1 and Its Potential in Vaccine Development

Carpio, KL, Barrett, ADT

Vaccines (Basel) 2021
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
protein homooligomerization (0051260)
Disease
Name Identifier Synonyms
dengue disease DOID:12205 breakbone fever, Dengue Fever, classic dengue
Cross References
Mondo
Authored
Stephan, R  (2024-08-19)
Reviewed
Mansur, DS  (2025-09-18)
Roque Ascenção, F  (2025-10-29)
Created
Stephan, R  (2024-08-29)
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