Reactome | Negative regulation by 'Importin alpha:Ivermectin [cytosol]'

Schema > NegativeRegulation > Entries

activity	[GO_MolecularFunction:447788] protein folding chaperone
created	[InstanceEdit:9924249] Stephan, Ralf, 2024-10-11
dbId	9924261
displayName	Negative regulation by 'Importin alpha:Ivermectin [cytosol]'
modified	[InstanceEdit:9954417] Stephan, Ralf, 2025-06-07
regulatedEntity	[BlackBoxEvent:R-HSA-9945325] NS3 localizes to nucleus - Homo sapiens [BlackBoxEvent:R-HSA-9919966] NS5 localizes to nucleus - Homo sapiens
regulator	[Complex:R-HSA-9924245] Importin alpha:Ivermectin [cytosol]
schemaClass	NegativeRegulation

(regulatedBy)	[BlackBoxEvent:R-HSA-9945325] NS3 localizes to nucleus [BlackBoxEvent:R-HSA-9919966] NS5 localizes to nucleus
(regulation)	[RegulationReference:9924240] Negative regulation by 'Importin:Ivermectin [cytosol]' Dengue virus NS1 secretion is regulated via importin-subunit ?1 controlling expression of the chaperone GRp78 and targeted by the clinical drug ivermectin

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