Reactome | CK2alpha phosphorylates BMAL1 (ARNTL) on serine-90

Schema > Reaction > Entries

CK2alpha phosphorylates BMAL1 (ARNTL) on serine-90 Show undefined attributes

authored	[InstanceEdit:9911591] May, Bruce, 2024-06-01
catalystActivity	[CatalystActivity:9920727] protein serine/threonine kinase activity of CSNK2A1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9912395] May, Bruce, 2024-06-08
dbId	9912401
deleted	[Deleted:9938750] Deletion of instance: 421320 [Deleted:9032440] Deletion of instance: 5334727
displayName	CK2alpha phosphorylates BMAL1 (ARNTL) on serine-90
edited	[InstanceEdit:9911591] May, Bruce, 2024-06-01
eventOf	[Pathway:R-HSA-9931529] Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK - Homo sapiens
followingEvent	[Reaction:R-HSA-9912390] p-S90-BMAL1 binds p-T451,T461-CLOCK - Homo sapiens
inferredFrom	[Reaction:R-MMU-9912393] CK2alpha phosphorylates Bmal1 (Arntl) on serine-97 - Mus musculus
input	[EntityWithAccessionedSequence:R-HSA-400353] ARNTL [cytosol] [SimpleEntity:R-ALL-29358] ATP [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
maxDepth	1
modified	[InstanceEdit:9938697] May, Bruce, 2025-02-18
name	CK2alpha phosphorylates BMAL1 (ARNTL) on serine-90
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9912391] p-S90-BMAL1 [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-9911580] RORA,B,C positively regulates expression and NR1D1 (REV-ERBA) negatively regulates expression of BMAL1 (ARNTL) - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
regulatedBy	[NegativeRegulation:9923129] Negative regulation by 'CSNK2B [nucleoplasm]'
releaseDate	2025-03-26
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9938389] Sancar, Aziz, 2025-02-14 [InstanceEdit:9938694] Albrecht, Urs, 2025-02-18
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9912401
summation	[Summation:9928737] CK2alpha, the catalytic subunit of casein kinase II (CK2) ph...

Referrals

(replacementInstances)	[Deleted:9032440] Deletion of instance: 5334727 [Deleted:9938750] Deletion of instance: 421320
(hasEvent)	[Pathway:R-HSA-9931529] Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK
(precedingEvent)	[Reaction:R-HSA-9912390] p-S90-BMAL1 binds p-T451,T461-CLOCK
(inferredTo)	[Reaction:R-MMU-9912393] CK2alpha phosphorylates Bmal1 (Arntl) on serine-97

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