Reactome | p-S90-BMAL1 binds p-T451,T461-CLOCK

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p-S90-BMAL1 binds p-T451,T461-CLOCK Show undefined attributes

authored	[InstanceEdit:9911591] May, Bruce, 2024-06-01
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9912395] May, Bruce, 2024-06-08
dbId	9912390
deleted	[Deleted:9938747] Deletion of instance: 400228
displayName	p-S90-BMAL1 binds p-T451,T461-CLOCK
edited	[InstanceEdit:9911591] May, Bruce, 2024-06-01
eventOf	[Pathway:R-HSA-9931529] Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9920665] p-S90-BMAL1:p-T451,T461-CLOCK translocates from the cytosol to the nucleus - Homo sapiens
inferredFrom	[Reaction:R-MMU-9920721] p-S97-Bmal1 binds p-T451,T461-Clock - Mus musculus
input	[EntityWithAccessionedSequence:R-HSA-9912391] p-S90-BMAL1 [cytosol] [EntityWithAccessionedSequence:R-HSA-9912397] p-T451,T461-CLOCK [cytosol]
isChimeric	false
isInDisease	false
isInferred	true
maxDepth	1
modified	[InstanceEdit:9938697] May, Bruce, 2025-02-18
name	p-S90-BMAL1 binds p-T451,T461-CLOCK p-S90-ARNTL binds p-T451,T461-CLOCK
output	[Complex:R-HSA-9912404] p-S90-BMAL1:p-T451,T461-CLOCK [cytosol]
precedingEvent	[Reaction:R-HSA-9912401] CK2alpha phosphorylates BMAL1 (ARNTL) on serine-90 - Homo sapiens [Reaction:R-HSA-9912396] CDK5 phosphorylates CLOCK on serine-451 and serine-461 - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-03-26
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9938389] Sancar, Aziz, 2025-02-14 [InstanceEdit:9938694] Albrecht, Urs, 2025-02-18
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9912390
summation	[Summation:9928751] In the cytosol, phosphorylated CLOCK binds phosphorylated BM...

Referrals

(replacementInstances)	[Deleted:9938747] Deletion of instance: 400228
(hasEvent)	[Pathway:R-HSA-9931529] Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK
(precedingEvent)	[BlackBoxEvent:R-HSA-9920665] p-S90-BMAL1:p-T451,T461-CLOCK translocates from the cytosol to the nucleus
(inferredTo)	[Reaction:R-MMU-9920721] p-S97-Bmal1 binds p-T451,T461-Clock

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