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p-S90-BMAL1 binds p-T451,T461-CLOCK
Stable Identifier
R-HSA-9912390
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p-S90-ARNTL binds p-T451,T461-CLOCK
ReviewStatus
5/5
Locations in the PathwayBrowser
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Circadian clock (Homo sapiens)
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK (Homo sapiens)
p-S90-BMAL1 binds p-T451,T461-CLOCK (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
In the cytosol, phosphorylated CLOCK binds phosphorylated BMAL1 (ARNTL1) (inferred from mouse homologs) prior to translocation of the BMAL1:CLOCK heterodimer to the nucleus (inferred from mouse homologs).
Participants
Input
p-S90-BMAL1 [cytosol]
(Homo sapiens)
p-T451,T461-CLOCK [cytosol]
(Homo sapiens)
Output
p-S90-BMAL1:p-T451,T461-CLOCK [cytosol]
(Homo sapiens)
Participates
as an event of
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK (Homo sapiens)
Inferred From
p-S97-Bmal1 binds p-T451,T461-Clock (Mus musculus)
Authored
May, B (2024-06-01)
Reviewed
Sancar, A (2025-02-14)
Albrecht, U (2025-02-18)
Created
May, B (2024-06-08)
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