Reactome | CPT1B transfers PALM to CAR

Schema > Reaction > Entries

CPT1B transfers PALM to CAR Show undefined attributes

authored	[InstanceEdit:9911357] D'Eustachio, Peter, 2024-05-29
catalystActivity	[CatalystActivity:9911359] carnitine O-palmitoyltransferase activity of CPT1B [mitochondrial outer membrane]
catalystActivityReference	[CatalystActivityReference:9911370] carnitine O-palmitoyltransferase activity of CPT1B [mitochondrial outer membrane] Functional studies of yeast-expressed human heart muscle carnitine palmitoyltransferase I
category	transition
compartment	[Compartment:70101] cytosol [Compartment:17906] mitochondrial outer membrane [Compartment:17927] mitochondrial intermembrane space
created	[InstanceEdit:9911357] D'Eustachio, Peter, 2024-05-29
crossReference	[DatabaseIdentifier:12667828] RHEA:12661 [DatabaseIdentifier:9911369] RHEA:12662
dbId	9911362
displayName	CPT1B transfers PALM to CAR
edited	[InstanceEdit:9911357] D'Eustachio, Peter, 2024-05-29
eventOf	[Pathway:R-HSA-200425] Carnitine shuttle - Homo sapiens
followingEvent	[Reaction:R-HSA-200424] Exchange of acylcarnitine and carnitine across the inner mitochondrial membrane - Homo sapiens
input	[SimpleEntity:R-ALL-549207] CAR [mitochondrial intermembrane space] [SimpleEntity:R-ALL-200993] PALM-CoA [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:549202] Functional studies of yeast-expressed human heart muscle carnitine palmitoyltransferase I
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	CPT1B transfers PALM to CAR (R)-carnitine + hexadecanoyl-CoA => CoA + O-hexadecanoyl-(R)-carnitine palmitoyl-CoA + carnitine => palmitoylcarnitine + CoASH
orthologousEvent	[Reaction:R-CFA-9911362] CPT1B transfers PALM to CAR - Canis familiaris [Reaction:R-CEL-9911362] CPT1B transfers PALM to CAR - Caenorhabditis elegans [Reaction:R-DME-9911362] CPT1B transfers PALM to CAR - Drosophila melanogaster [Reaction:R-XTR-9911362] CPT1B transfers PALM to CAR - Xenopus tropicalis [Reaction:R-DRE-9911362] CPT1B transfers PALM to CAR - Danio rerio [Reaction:R-SSC-9911362] CPT1B transfers PALM to CAR - Sus scrofa [Reaction:R-BTA-9911362] CPT1B transfers PALM to CAR - Bos taurus [Reaction:R-RNO-9911362] CPT1B transfers PALM to CAR - Rattus norvegicus [Reaction:R-MMU-9911362] CPT1B transfers PALM to CAR - Mus musculus
output	[SimpleEntity:R-ALL-76194] CoA-SH [cytosol] [SimpleEntity:R-ALL-201034] L-PCAR [mitochondrial intermembrane space]
precedingEvent	[BlackBoxEvent:R-HSA-8949399] CAR translocates from the cytosol to the mitochondrial intermembrane space - Homo sapiens [Reaction:R-HSA-434382] ACSL3,4 ligates coenzyme A (CoA-SH) to a long chain fatty acid yielding fatty acyl-coenzyme A - Homo sapiens [Reaction:R-HSA-5634100] FABP5 dissociates from RXRA:PPARD:atRA - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
regulatedBy	[NegativeRegulation:R-HSA-200418] Negative regulation by 'Mal-CoA [cytosol]'
regulationReference	[RegulationReference:9642880] Negative regulation by 'Mal-CoA [cytosol]' Structural model of a malonyl-CoA-binding site of carnitine octanoyltransferase and carnitine palmitoyltransferase I: mutational analysis of a malonyl-CoA affinity domain
releaseDate	2024-09-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9917333] Hill, David P, 2024-08-02
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9911362
summation	[Summation:9911368] Carnitine palmitoyl transferase 1B (CPT1B) associated with t...

Referrals

(hasEvent)	[Pathway:R-HSA-200425] Carnitine shuttle
(precedingEvent)	[Reaction:R-HSA-200424] Exchange of acylcarnitine and carnitine across the inner mitochondrial membrane