Carnitine palmitoyl transferase 1B (CPT1B) associated with t...

created [InstanceEdit:9911357] D'Eustachio, Peter, 2024-05-29
dbId 9911368
displayName Carnitine palmitoyl transferase 1B (CPT1B) associated with t...
modified [InstanceEdit:9911373] D'Eustachio, Peter, 2024-05-29
schemaClass Summation
text Carnitine palmitoyl transferase 1B (CPT1B) associated with the inner mitochondrial membrane, catalyzes the reaction of palmitoyl-CoA (PALM-CoA) from the cytosol with carnitine (CAR) in the mitochondrial intermembrane space to form palmitoylcarnitine (L-PCARN) and CoA-SH. Three CPT1 isoforms exist; CPT1A, B and C. In the body, CPT1A is most abundant in liver while CPT1B is abundant in muscle. CPT1C is mainly expressed in neurons and localises to the ER and not to the mitochondria. It has little or no enzymatic activity in fatty acid oxidation. Both CPT1A and CPT1B are inhibited by malonyl-CoA (Morillas et al. 2002, 2004; Zammit et al. 2001; Zhu et al. 1997).
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