Reactome | Modulation of host responses by IFN-stimulated genes

Schema > Pathway > Entries

Modulation of host responses by IFN-stimulated genes Show undefined attributes

authored	[InstanceEdit:9909522] Shamovsky, Veronica, 2024-05-14
created	[InstanceEdit:9909522] Shamovsky, Veronica, 2024-05-14
dbId	9909505
displayName	Modulation of host responses by IFN-stimulated genes
doi	10.3180/R-HSA-9909505.1
edited	[InstanceEdit:9927234] Shamovsky, Veronica, 2024-11-05
eventOf	[Pathway:R-HSA-913531] Interferon Signaling - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-9909510] FKBP5 binds CHUK:IKBKB:IKBKG - Homo sapiens [Reaction:R-HSA-9909519] IFI44, IFI44L binds FKBP5 - Homo sapiens [Reaction:R-HSA-9921830] IFI6, IFI27 binds DDX58 - Homo sapiens [Reaction:R-HSA-9924831] IFI27 binds IFIH1 - Homo sapiens [Reaction:R-HSA-9921802] IFI6 binds HSPA5 - Homo sapiens [Reaction:R-HSA-9927247] ISGylation of DDX58 (RIG-I) - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9921798] Interferon alpha inducible protein 6 is a negative regulator of innate immune responses by modulating RIG-I activation [LiteratureReference:9909495] Interferon-Induced Protein 44 Interacts with Cellular FK506-Binding Protein 5, Negatively Regulates Host Antiviral Responses, and Supports Virus Replication [LiteratureReference:9909503] Novel Functions of IFI44L as a Feedback Regulator of Host Antiviral Responses [LiteratureReference:9924332] The IFN-stimulated gene IFI27 counteracts innate immune responses after viral infections by interfering with RIG-I signaling [LiteratureReference:936533] Negative feedback regulation of RIG-I-mediated antiviral signaling by interferon-induced ISG15 conjugation
maxDepth	2
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	Modulation of host responses by IFN-stimulated genes
orthologousEvent	[Pathway:R-DDI-9909505] Modulation of host responses by IFN-stimulated genes - Dictyostelium discoideum [Pathway:R-CEL-9909505] Modulation of host responses by IFN-stimulated genes - Caenorhabditis elegans [Pathway:R-DME-9909505] Modulation of host responses by IFN-stimulated genes - Drosophila melanogaster [Pathway:R-GGA-9909505] Modulation of host responses by IFN-stimulated genes - Gallus gallus [Pathway:R-DRE-9909505] Modulation of host responses by IFN-stimulated genes - Danio rerio [Pathway:R-SSC-9909505] Modulation of host responses by IFN-stimulated genes - Sus scrofa [Pathway:R-BTA-9909505] Modulation of host responses by IFN-stimulated genes - Bos taurus [Pathway:R-RNO-9909505] Modulation of host responses by IFN-stimulated genes - Rattus norvegicus [Pathway:R-MMU-9909505] Modulation of host responses by IFN-stimulated genes - Mus musculus
releaseDate	2024-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9928189] Phair, Robert, 2024-11-12
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9909505
summation	[Summation:9909496] Excessive or long-lasting innate immune responses can be har...

Referrals

(hasEvent)

[Pathway:R-HSA-913531] Interferon Signaling

Cite Us!