Reactome | Excessive or long-lasting innate immune responses can be har...

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created	[InstanceEdit:9909522] Shamovsky, Veronica, 2024-05-14
dbId	9909496
displayName	Excessive or long-lasting innate immune responses can be har...
literatureReference	[LiteratureReference:9921798] Interferon alpha inducible protein 6 is a negative regulator of innate immune responses by modulating RIG-I activation [LiteratureReference:9909495] Interferon-Induced Protein 44 Interacts with Cellular FK506-Binding Protein 5, Negatively Regulates Host Antiviral Responses, and Supports Virus Replication [LiteratureReference:9909503] Novel Functions of IFI44L as a Feedback Regulator of Host Antiviral Responses [LiteratureReference:9924332] The IFN-stimulated gene IFI27 counteracts innate immune responses after viral infections by interfering with RIG-I signaling
modified	[InstanceEdit:9924827] Shamovsky, Veronica, 2024-10-16
schemaClass	Summation
text	Excessive or long-lasting innate immune responses can be harmful to the host, so negative feedback mechanisms are essential. This Reactome pathway describes regulatory functions of selected interferon (IFN)-stimulated genes (ISGs) such as IFI44, IFI44L, IFI6 and IFI27 that suppress the IFN-mediated innate immune responses triggered by viral infections (DeDiego ML et al., 2019a, b; Villamayor L, L�pez-Garc�a D et al., 2023; Villamayor L, Rivero V et al., 2023).

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