Reactome | Modulation of host responses by IFN-stimulated genes

Modulation of host responses by IFN-stimulated genes

Stable Identifier

R-HSA-9909505

DOI

10.3180/R-HSA-9909505.1

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Modulation of host responses by IFN-stimulated genes

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Excessive or long-lasting innate immune responses can be harmful to the host, so negative feedback mechanisms are essential. This Reactome pathway describes regulatory functions of selected interferon (IFN)-stimulated genes (ISGs) such as IFI44, IFI44L, IFI6 and IFI27 that suppress the IFN-mediated innate immune responses triggered by viral infections (DeDiego ML et al., 2019a, b; Villamayor L, López-García D et al., 2023; Villamayor L, Rivero V et al., 2023).

Literature References

PubMed ID	Title	Journal	Year
18057259	Negative feedback regulation of RIG-I-mediated antiviral signaling by interferon-induced ISG15 conjugation Kim, MJ, Hwang, SY, Imaizumi, T, Yoo, JY	J Virol	2008
37187533	The IFN-stimulated gene IFI27 counteracts innate immune responses after viral infections by interfering with RIG-I signaling Villamayor, L, López-García, D, Rivero, V, Martínez-Sobrido, L, Nogales, A, DeDiego, ML	Front Microbiol	2023
31434731	Novel Functions of IFI44L as a Feedback Regulator of Host Antiviral Responses DeDiego, ML, Martínez-Sobrido, L, Topham, DJ	J Virol	2019
36793726	Interferon alpha inducible protein 6 is a negative regulator of innate immune responses by modulating RIG-I activation Villamayor, L, Rivero, V, López-García, D, Topham, DJ, Martínez-Sobrido, L, Nogales, A, DeDiego, ML	Front Immunol	2023
31455651	Interferon-Induced Protein 44 Interacts with Cellular FK506-Binding Protein 5, Negatively Regulates Host Antiviral Responses, and Supports Virus Replication DeDiego, ML, Nogales, A, Martínez-Sobrido, L, Topham, DJ	mBio	2019