Modulation of host responses by IFN-stimulated genes

Stable Identifier
R-HSA-9909505
DOI
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser
Excessive or long-lasting innate immune responses can be harmful to the host, so negative feedback mechanisms are essential. This Reactome pathway describes regulatory functions of selected interferon (IFN)-stimulated genes (ISGs) such as IFI44, IFI44L, IFI6 and IFI27 that suppress the IFN-mediated innate immune responses triggered by viral infections (DeDiego ML et al., 2019a, b; Villamayor L, López-García D et al., 2023; Villamayor L, Rivero V et al., 2023).
Literature References
PubMed ID Title Journal Year
18057259 Negative feedback regulation of RIG-I-mediated antiviral signaling by interferon-induced ISG15 conjugation

Kim, MJ, Hwang, SY, Imaizumi, T, Yoo, JY

J Virol 2008
37187533 The IFN-stimulated gene IFI27 counteracts innate immune responses after viral infections by interfering with RIG-I signaling

Villamayor, L, López-García, D, Rivero, V, Martínez-Sobrido, L, Nogales, A, DeDiego, ML

Front Microbiol 2023
31434731 Novel Functions of IFI44L as a Feedback Regulator of Host Antiviral Responses

DeDiego, ML, Martínez-Sobrido, L, Topham, DJ

J Virol 2019
36793726 Interferon alpha inducible protein 6 is a negative regulator of innate immune responses by modulating RIG-I activation

Villamayor, L, Rivero, V, López-García, D, Topham, DJ, Martínez-Sobrido, L, Nogales, A, DeDiego, ML

Front Immunol 2023
31455651 Interferon-Induced Protein 44 Interacts with Cellular FK506-Binding Protein 5, Negatively Regulates Host Antiviral Responses, and Supports Virus Replication

DeDiego, ML, Nogales, A, Martínez-Sobrido, L, Topham, DJ

mBio 2019
Participants
Participates
Orthologous Events
Authored
Reviewed
Created
Cite Us!