Reactome | P2RX7 in ATP:P2RX7:PANX1 transports cations from the extracellular region to the cytosol

Schema > Reaction > Entries

P2RX7 in ATP:P2RX7:PANX1 transports cations from the extracellular region to the cytosol Show undefined attributes

authored	[InstanceEdit:9892589] May, Bruce, 2024-03-28
catalystActivity	[CatalystActivity:9905926] extracellularly ATP-gated monoatomic cation channel activity of ATP:P2X7 oligomer:PANX1 heptamer [plasma membrane]
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9905924] May, Bruce, 2024-03-29
crossReference	[DatabaseIdentifier:12668135] RHEA:29255
dbId	9905964
displayName	P2RX7 in ATP:P2RX7:PANX1 transports cations from the extracellular region to the cytosol
edited	[InstanceEdit:9892589] May, Bruce, 2024-03-28
eventOf	[Pathway:R-HSA-9856532] Mechanical load activates signaling by PIEZO1 and integrins in osteocytes - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9906597] Activation of AKT1 by shear stress in osteocytes - Homo sapiens [Reaction:R-HSA-9905999] Pannexin1 (PANX1) channel in a complex with P2RX7 transports ATP from the cytosol to the extracellular region - Homo sapiens
inferredFrom	[Reaction:R-MMU-9907479] P2rx7 in ATP:P2rx7:Panx1 transports cations from the extracellular region to the cytosol - Mus musculus [Reaction:R-RNO-9907601] P2rx7 trimer translocates cations from the extracellular region to the cytosol - Rattus norvegicus
input	[SimpleEntity:R-ALL-74112] Ca2+ [extracellular region] [SimpleEntity:R-ALL-74113] Na+ [extracellular region]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:9907476] The ATP4- receptor-operated channel (P2Z class) of human lymphocytes allows Ba2+ and ethidium+ uptake: inhibition of fluxes by suramin [LiteratureReference:9907469] Partial agonists and antagonists reveal a second permeability state of human lymphocyte P2Z/P2X7 channel [LiteratureReference:9907449] Isoquinolines as antagonists of the P2X7 nucleotide receptor: high selectivity for the human versus rat receptor homologues [LiteratureReference:9907455] The permeabilizing ATP receptor, P2X7. Cloning and expression of a human cDNA [LiteratureReference:9907605] Influence of extracellular monovalent cations on pore and gating properties of P2X7 receptor-operated single-channel currents
maxDepth	1
modified	[InstanceEdit:9927250] May, Bruce, 2024-11-05
name	P2RX7 in ATP:P2RX7:PANX1 transports cations from the extracellular region to the cytosol
output	[SimpleEntity:R-ALL-74016] Ca2+ [cytosol] [SimpleEntity:R-ALL-83910] Na+ [cytosol]
precedingEvent	[Reaction:R-HSA-9905952] ATP binds P2RX7 in P2RX7 trimer:PANX1 heptamer - Homo sapiens
releaseDate	2024-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9925857] Farach-Carson, Mary C, 2024-10-27 [InstanceEdit:9925859] Wu, Danielle, 2024-10-27
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9905964
summation	[Summation:9907474] ATP activates the P2RX7 (P2X7, P2Z) trimer to passively tran...

Referrals

(hasEvent)	[Pathway:R-HSA-9856532] Mechanical load activates signaling by PIEZO1 and integrins in osteocytes
(precedingEvent)	[Reaction:R-HSA-9905999] Pannexin1 (PANX1) channel in a complex with P2RX7 transports ATP from the cytosol to the extracellular region [BlackBoxEvent:R-HSA-9906597] Activation of AKT1 by shear stress in osteocytes
(inferredTo)	[Reaction:R-RNO-9907601] P2rx7 trimer translocates cations from the extracellular region to the cytosol [Reaction:R-MMU-9907479] P2rx7 in ATP:P2rx7:Panx1 transports cations from the extracellular region to the cytosol