Reactome | ATP activates the P2RX7 (P2X7, P2Z) trimer to passively tran...

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created	[InstanceEdit:9907471] May, Bruce, 2024-04-10
dbId	9907474
displayName	ATP activates the P2RX7 (P2X7, P2Z) trimer to passively tran...
literatureReference	[LiteratureReference:9907451] P2X7 receptors: channels, pores and more [LiteratureReference:9907602] The Elusive P2X7 Macropore [LiteratureReference:9905957] P2X7R-Panx1 Complex Impairs Bone Mechanosignaling under High Glucose Levels Associated with Type-1 Diabetes
modified	[InstanceEdit:9909064] May, Bruce, 2024-04-25
schemaClass	Summation
text	ATP activates the P2RX7 (P2X7, P2Z) trimer to passively transport cations, notably calcium (Wiley et al. 1993, Humphreys et al. 1998, Wiley et al. 1998, Riedel et al. 2007, and inferred from the rat homologue, reviewed in Volont� et al. 2012, Di Virgilio et al. 2018). Calcium and sodium ions follow their concentration gradients from the extracellular region to the cytosol. In mouse osteocytes, P2rx7 is located at the plasma membrane in a complex with the Pannexin1 (Panx1) anion channel (Seref-Ferlengez et al. 2016).

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