Reactome | TIMM21 carries COX4, COX5A, COX6C to MT-CO1:MITRAC

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TIMM21 carries COX4, COX5A, COX6C to MT-CO1:MITRAC Show undefined attributes

authored	[InstanceEdit:9865421] Stephan, Ralf, 2024-03-12
category	binding
compartment	[Compartment:70616] mitochondrial inner membrane [Compartment:17927] mitochondrial intermembrane space
created	[InstanceEdit:9865414] Stephan, Ralf, 2024-03-12
dbId	9865412
displayName	TIMM21 carries COX4, COX5A, COX6C to MT-CO1:MITRAC
edited	[InstanceEdit:9910822] Stephan, Ralf, 2024-05-21
eventOf	[Pathway:R-HSA-9864848] Complex IV assembly - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9865309] MT-CO1 mRNA is translated - Homo sapiens [Reaction:R-HSA-9865449] Metallochaperone inserts Cu2+ into MT-CO1 - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:18876] protein insertion into mitochondrial inner membrane
input	[Complex:R-HSA-9865433] MT-CO1:Mg2+:PE:CL:MITRAC [mitochondrial inner membrane] [Complex:R-HSA-9865418] TIMM21:COX4:COX5A:COX6C [mitochondrial intermembrane space]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9865346] A CMC1-knockout reveals translation-independent control of human mitochondrial complex IV biogenesis [LiteratureReference:8986109] MITRAC links mitochondrial protein translocation to respiratory-chain assembly and translational regulation [LiteratureReference:9865349] MITRAC7 Acts as a COX1-Specific Chaperone and Reveals a Checkpoint during Cytochrome c Oxidase Assembly
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	TIMM21 carries COX4, COX5A, COX6C to MT-CO1:MITRAC
orthologousEvent	[Reaction:R-DME-9865412] TIMM21 carries COX4, COX5A, COX6C to MT-CO1:MITRAC - Drosophila melanogaster [Reaction:R-DRE-9865412] TIMM21 carries COX4, COX5A, COX6C to MT-CO1:MITRAC - Danio rerio [Reaction:R-SSC-9865412] TIMM21 carries COX4, COX5A, COX6C to MT-CO1:MITRAC - Sus scrofa [Reaction:R-BTA-9865412] TIMM21 carries COX4, COX5A, COX6C to MT-CO1:MITRAC - Bos taurus [Reaction:R-CFA-9865412] TIMM21 carries COX4, COX5A, COX6C to MT-CO1:MITRAC - Canis familiaris [Reaction:R-MMU-9865412] TIMM21 carries COX4, COX5A, COX6C to MT-CO1:MITRAC - Mus musculus
output	[Complex:R-HSA-9865410] MT-CO1:Mg2+:PE:CL:MITRAC:TIMM21:COX4:COX5A:COX6C [mitochondrial inner membrane]
precedingEvent	[BlackBoxEvent:R-HSA-9865350] Nascent MT-CO1 binds to MITRAC, Mg2+, PE, CL - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2024-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9910688] Hill, David P, 2024-05-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9865412
summation	[Summation:9865432] Mitochondrial import inner membrane translocase subunit TIMM...

Referrals

(hasEvent)	[Pathway:R-HSA-9864848] Complex IV assembly
(precedingEvent)	[BlackBoxEvent:R-HSA-9865309] MT-CO1 mRNA is translated [Reaction:R-HSA-9865449] Metallochaperone inserts Cu2+ into MT-CO1