Reactome | TIMM21 carries COX4, COX5A, COX6C to MT-CO1:MITRAC

TIMM21 carries COX4, COX5A, COX6C to MT-CO1:MITRAC

Stable Identifier

R-HSA-9865412

Type

Reaction [binding]

Species

Homo sapiens

Compartment

mitochondrial inner membrane, mitochondrial intermembrane space

ReviewStatus

5/5

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TIMM21 carries COX4, COX5A, COX6C to MT-CO1:MITRAC

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Mitochondrial import inner membrane translocase subunit TIMM21 (TIM21, C18orf55) carries the Complex IV subunits COX4 (either the ubiquitous isoform COX4I1 or the tissue-specific, predominantly lung isoform COX4I2), COX5A and COX6C across the inner membrane, where they bind to the MT-CO1:MITRAC complex (Mick et al., 2012; Dennerlein et al., 2015; Bourens & Barrientos, 2017).

Literature References

PubMed ID	Title	Journal	Year
23260140	MITRAC links mitochondrial protein translocation to respiratory-chain assembly and translational regulation Lorenzi, I, Wiese, H, Reinhold, R, Warscheid, B, Sasarman, F, Rehling, P, Shoubridge, EA, Weraarpachai, W, Mick, DU, Dennerlein, S, Pacheu-Grau, D	Cell	2012
28082314	A CMC1-knockout reveals translation-independent control of human mitochondrial complex IV biogenesis Bourens, M, Barrientos, A	EMBO Rep	2017
26321642	MITRAC7 Acts as a COX1-Specific Chaperone and Reveals a Checkpoint during Cytochrome c Oxidase Assembly Deckers, M, Hellwig, C, Warscheid, B, Jakobs, S, Bareth, B, Rehling, P, Jans, D, Oeljeklaus, S, Dennerlein, S	Cell Rep	2015