Reactome | Phosphorylation of ABL1 on tyrosine-393 in response to oscillatory shear stress

Schema > BlackBoxEvent > Entries

Phosphorylation of ABL1 on tyrosine-393 in response to oscillatory shear stress Show undefined attributes

authored	[InstanceEdit:9864838] May, Bruce, 2024-03-07
category	uncertain
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9865219] May, Bruce, 2024-03-09
dbId	9865184
displayName	Phosphorylation of ABL1 on tyrosine-393 in response to oscillatory shear stress
edited	[InstanceEdit:9864838] May, Bruce, 2024-03-07
eventOf	[Pathway:R-HSA-9860927] Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells - Homo sapiens
followingEvent	[Reaction:R-HSA-9865196] p-Y393-ABL1 phosphorylates tyrosine-407 of YAP1 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-375987] ABL1 [cytosol] [SimpleEntity:R-ALL-113592] ATP [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9865247] c-Abl regulates YAPY357 phosphorylation to activate endothelial atherogenic responses to disturbed flow
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Phosphorylation of ABL1 on tyrosine-393 in response to oscillatory shear stress
orthologousEvent	[BlackBoxEvent:R-CEL-9865184] Phosphorylation of ABL1 on tyrosine-393 in response to oscillatory shear stress - Caenorhabditis elegans [BlackBoxEvent:R-DME-9865184] Phosphorylation of ABL1 on tyrosine-393 in response to oscillatory shear stress - Drosophila melanogaster [BlackBoxEvent:R-GGA-9865184] Phosphorylation of ABL1 on tyrosine-393 in response to oscillatory shear stress - Gallus gallus [BlackBoxEvent:R-XTR-9865184] Phosphorylation of ABL1 on tyrosine-393 in response to oscillatory shear stress - Xenopus tropicalis [BlackBoxEvent:R-DRE-9865184] Phosphorylation of ABL1 on tyrosine-393 in response to oscillatory shear stress - Danio rerio [BlackBoxEvent:R-SSC-9865184] Phosphorylation of ABL1 on tyrosine-393 in response to oscillatory shear stress - Sus scrofa [BlackBoxEvent:R-BTA-9865184] Phosphorylation of ABL1 on tyrosine-393 in response to oscillatory shear stress - Bos taurus [BlackBoxEvent:R-CFA-9865184] Phosphorylation of ABL1 on tyrosine-393 in response to oscillatory shear stress - Canis familiaris [BlackBoxEvent:R-RNO-9865184] Phosphorylation of ABL1 on tyrosine-393 in response to oscillatory shear stress - Rattus norvegicus [BlackBoxEvent:R-MMU-9865184] Phosphorylation of ABL1 on tyrosine-393 in response to oscillatory shear stress - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-9865161] p-Y393-ABL1 [cytosol]
precedingEvent	[Reaction:R-HSA-9865228] p-S26-ANXA2:integrin alpha5:integrin beta1 (p-S26-ANXA2:ITGA5:ITGB1) binds fibronectin (FN1) matrix - Homo sapiens
regulatedBy	[PositiveRegulation:9865223] Positive regulation by 'p-S26-ANXA2:ITGA5:ITGB1:Ca2+:fibronectin [plasma membrane]'
releaseDate	2024-09-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9915793] Xiao, Rui, 2024-07-16
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9865184
summation	[Summation:9865527] Through an uncharacterized mechanism, oscillatory shear stre...

Referrals

(hasEvent)	[Pathway:R-HSA-9860927] Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
(precedingEvent)	[Reaction:R-HSA-9865196] p-Y393-ABL1 phosphorylates tyrosine-407 of YAP1