Reactome | Phosphorylation of ABL1 on tyrosine-393 in response to oscillatory shear stress

Schema > BlackBoxEvent > Entries

Phosphorylation of ABL1 on tyrosine-393 in response to oscillatory shear stress Show undefined attributes

category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10326001
displayName	Phosphorylation of ABL1 on tyrosine-393 in response to oscillatory shear stress
eventOf	[Pathway:R-CFA-9860927] Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-9865196] p-Y393-ABL1 phosphorylates tyrosine-407 of YAP1 - Canis familiaris
inferredFrom	[BlackBoxEvent:R-HSA-9865184] Phosphorylation of ABL1 on tyrosine-393 in response to oscillatory shear stress - Homo sapiens
input	[EntityWithAccessionedSequence:R-CFA-375987] ABL1 [cytosol] [SimpleEntity:R-ALL-113592] ATP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Phosphorylation of ABL1 on tyrosine-393 in response to oscillatory shear stress
output	[EntityWithAccessionedSequence:R-CFA-9865161] phospho-p-Y393-ABL1 [cytosol]
regulatedBy	[PositiveRegulation:10325888] Positive regulation by 'p-S26-ANXA2:ITGA5:ITGB1:Ca2+:fibronectin [plasma membrane]'
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:49646] Canis familiaris
stId	R-CFA-9865184
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-9860927] Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
(precedingEvent)	[Reaction:R-CFA-9865196] p-Y393-ABL1 phosphorylates tyrosine-407 of YAP1
(inferredTo)	[BlackBoxEvent:R-HSA-9865184] Phosphorylation of ABL1 on tyrosine-393 in response to oscillatory shear stress

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