Reactome | ME1 tetramer decarboxylates OA to PYR

ME1 tetramer decarboxylates OA to PYR

Stable Identifier

R-HSA-9861660

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Cytosolic malic enzyme (ME1, aka c-NADP-ME) oxidatively decarboxylates oxaloacetate (OA) to pyruvate (PYR). As the catalytic rate of this reaction is 5-25% of that of malate decarboxylation, its relevance is unclear ((Zelewski & Swierczyński, 1991; Bukato et al., 1995). ME1 exists as a dimer of dimers (Murugan & Hung, 2012; Hsieh et al., 2014), and a divalent metal such as Mg2+ or Mn2+ is essential for catalysis (Bukato et al., 1995; Chang & Tong, 2003).

Literature References

PubMed ID	Title	Journal	Year
14596586	Structure and function of malic enzymes, a new class of oxidative decarboxylases Chang, GG, Tong, L	Biochemistry	2003
23284632	Biophysical characterization of the dimer and tetramer interface interactions of the human cytosolic malic enzyme Murugan, S, Hung, HC	PLoS ONE	2012
1935931	Malic enzyme in human liver. Intracellular distribution, purification and properties of cytosolic isozyme Zelewski, M, Swierczyński, J	Eur. J. Biochem.	1991
24998673	Structural characteristics of the nonallosteric human cytosolic malic enzyme Hsieh, JY, Li, SY, Chen, MC, Yang, PC, Chen, HY, Chan, NL, Liu, JH, Hung, HC	Biochim. Biophys. Acta	2014
7757881	Purification and properties of cytosolic and mitochondrial malic enzyme isolated from human brain Bukato, G, Kochan, Z, Swierczyński, J	Int J Biochem Cell Biol	1995