Reactome | prekallikrein:kininogen binds cell surface receptors

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prekallikrein:kininogen binds cell surface receptors Show undefined attributes

authored	[InstanceEdit:9929032] Shamovsky, Veronica, 2024-11-20
category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:9857940] Shamovsky, Veronica, 2024-01-09
dbId	9857952
displayName	prekallikrein:kininogen binds cell surface receptors
edited	[InstanceEdit:9937613] Shamovsky, Veronica, 2025-02-05
eventOf	[Pathway:R-HSA-9970672] FXIIa activates plasma kallikrein-kinin system - Homo sapiens
followingEvent	[Reaction:R-HSA-9857945] prekallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1-> kallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1 (PRCP catalyst) - Homo sapiens [Reaction:R-HSA-9655850] prekallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1-> kallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1 (FXIIa catalyst) - Homo sapiens
input	[DefinedSet:R-HSA-9857817] C1QBP, C1QBP:KRT1, PLAUR:KRT1 [plasma membrane] [Complex:R-HSA-9857934] KLKB1(20-638):KNG1(19-644) [extracellular region]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:158165] Isolation, cDNA cloning, and overexpression of a 33-kD cell surface glycoprotein that binds to the globular "heads" of C1q [LiteratureReference:158240] Identification of the zinc-dependent endothelial cell binding protein for high molecular weight kininogen and factor XII: identity with the receptor that binds to the globular "heads" of C1q (gC1q-R) [LiteratureReference:9936666] Interaction of high-molecular-weight kininogen with endothelial cell binding proteins suPAR, gC1qR and cytokeratin 1 determined by surface plasmon resonance (BiaCore) [LiteratureReference:158182] High molecular weight kininogen regulates prekallikrein assembly and activation on endothelial cells: a novel mechanism for contact activation [LiteratureReference:158256] Factor XII interacts with the multiprotein assembly of urokinase plasminogen activator receptor, gC1qR, and cytokeratin 1 on endothelial cell membranes [LiteratureReference:9857949] Factor XII and kininogen asymmetric assembly with gC1qR/C1QBP/P32 is governed by allostery [LiteratureReference:158381] Human high molecular weight kininogen. Studies of structure-function relationships and of proteolysis of the molecule occurring during contact activation of plasma. [LiteratureReference:158116] The relative priority of prekallikrein and factors XI/XIa assembly on cultured endothelial cells
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	prekallikrein:kininogen binds cell surface receptors KLKB1(20-638):KNG1(19-644) + C1QBP, C1QBP:KRT1, PLAUR:KRT1 -> KLKB1(20-638):KNG1(19-644):(C1QBP, C1QBP:KRT1, PLAUR:KRT1)
orthologousEvent	[Reaction:R-BTA-9857952] prekallikrein:kininogen binds cell surface receptors - Bos taurus [Reaction:R-GGA-9857952] prekallikrein:kininogen binds cell surface receptors - Gallus gallus [Reaction:R-XTR-9857952] prekallikrein:kininogen binds cell surface receptors - Xenopus tropicalis [Reaction:R-SSC-9857952] prekallikrein:kininogen binds cell surface receptors - Sus scrofa [Reaction:R-CFA-9857952] prekallikrein:kininogen binds cell surface receptors - Canis familiaris [Reaction:R-RNO-9857952] prekallikrein:kininogen binds cell surface receptors - Rattus norvegicus [Reaction:R-MMU-9857952] prekallikrein:kininogen binds cell surface receptors - Mus musculus
output	[Complex:R-HSA-9857960] KLKB1:KNG1:(C1QBP, C1QBP:KRT1, PLAUR:KRT1) [plasma membrane]
precedingEvent	[Reaction:R-HSA-9857939] prekallikrein + kininogen -> prekallikrein:kininogen - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
regulatedBy	[Requirement:R-HSA-158223] Requirement by 'Zn2+ [extracellular region]'
releaseDate	2026-03-25
releaseStatus	NEW
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9980333] Schmaier, Alvin H, 2026-01-27
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9857952
summation	[Summation:9857944] The prekallikrein (PK):kininogen (HK) complex, KLKB1(20?638)...

Referrals

(hasEvent)	[Pathway:R-HSA-9970672] FXIIa activates plasma kallikrein-kinin system
(precedingEvent)	[Reaction:R-HSA-9857945] prekallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1-> kallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1 (PRCP catalyst) [Reaction:R-HSA-9655850] prekallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1-> kallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1 (FXIIa catalyst)

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