Reactome | prekallikrein:kininogen binds cell surface receptors

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prekallikrein:kininogen binds cell surface receptors Show undefined attributes

category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10325721
displayName	prekallikrein:kininogen binds cell surface receptors
eventOf	[Pathway:R-CFA-9970672] FXIIa activates plasma kallikrein-kinin system - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-9857945] prekallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1-> kallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1 (PRCP catalyst) - Canis familiaris
inferredFrom	[Reaction:R-HSA-9857952] prekallikrein:kininogen binds cell surface receptors - Homo sapiens
input	[Complex:R-CFA-9857818] C1QBP homotrimer [plasma membrane] [Complex:R-CFA-9857934] KLKB1(20-638):KNG1(19-644) [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	prekallikrein:kininogen binds cell surface receptors KLKB1(20-638):KNG1(19-644) + C1QBP, C1QBP:KRT1, PLAUR:KRT1 -> KLKB1(20-638):KNG1(19-644):(C1QBP, C1QBP:KRT1, PLAUR:KRT1)
output	[Complex:R-CFA-9857960] KLKB1:KNG1:(C1QBP, C1QBP:KRT1, PLAUR:KRT1) [plasma membrane]
precedingEvent	[Reaction:R-CFA-9857939] prekallikrein + kininogen -> prekallikrein:kininogen - Canis familiaris
regulatedBy	[Requirement:R-HSA-159017] Requirement by 'Zn2+ [extracellular region]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-9857952
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-9970672] FXIIa activates plasma kallikrein-kinin system
(precedingEvent)	[Reaction:R-CFA-9857945] prekallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1-> kallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1 (PRCP catalyst)
(inferredTo)	[Reaction:R-HSA-9857952] prekallikrein:kininogen binds cell surface receptors

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